Showing papers on "Adenocarcinoma of the lung published in 1984"

Antigens Associated with a Human Lung Adenocarcinoma Defined by Monoclonal Antibodies

Abstract: Monoclonal antibodies KS1/4, KS1/9, and KS1/17 were developed in this laboratory from a fusion of the murine myeloma cell line P3X63Ag8 with spleens of BALB/c mice previously primed with UCLA P3 cells derived from a human adenocarcinoma of the lung. Monoclonal antibodies KS1/4 and KS1/17 seemed to recognize similar glycoprotein antigens on the lung carcinoma cells by indirect immunoprecipitation and sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis. However, mapping of [3H]lysine- and [3H]arginine-labeled tryptic peptides of antigens in specific immunoprecipitates of lung carcinoma cells by high-pressure liquid chromatography revealed a one peptide difference. Antibody KS1/9 did not immunoprecipitate any identifiable protein from detergent extracts of the immunizing cell line by routine methods and appears to detect a glycolipid antigen. Immunocytochemical analysis of tissue sections showed this monoclonal antibody to be reactive with adenocarcinomas of the lung and not with the other histological types of lung carcinoma or normal tissue. Monoclonal antibodies KS1/4 and KS1/17, however, reacted with 3 major histological types of lung cancer and minimally with the proximal tubules of normal kidney and the epithelium of bronchioles.

Dietary vitamin a and lung cancer risk: an analysis by histologic subtypes

Abstract: A case-control study was conducted based on 427 white males with lung cancer of the squamous, small cell, and adenocarcinoma histologic subtypes and 1,094 white male controls admitted to Roswell Park Memorial Institute between the years 1957 and 1965. The relation between selected dietary factors and lung cancer risk was examined for each histologic subtype while controlling for past cigarette use. Dietary vitamin A was found to be negatively associated with risk for squamous cell and small cell carcinoma, but not for adenocarcinoma of the lung. No significant association was observed, however, between dietary vitamin C, fats, or fiber and any of the lung cancer subtypes. These results suggest that the apparent protective effect of vitamin A in lung cancer may be histologic type-specific.

Enzyme-Linked Immunosorbent Assay for Human Manganese-Containing Superoxide Dismutase and Its Content in Lung Cancer

Abstract: A manganese-containing superoxide dismutase (Mn-SOD) was purified from human liver. Polyclonal antibody for the Mn-SOD was prepared in goat, and a simple and specific enzyme-linked immunosorbent assay (ELISA) for the Mn-SOD was developed. This assay was found to be sensitive to nanogram amounts of the enzyme. With respect to Mn-SOD levels of normal lung tissues, a positive correlation (r = 0.92, P less than .001) was observed between the results of enzymatic assay and those of immunochemical assay by ELISA. In lung carcinoma tissue the enzyme activity was in the same order of magnitude as in uninvolved tissues. However, the enzyme content determined by ELISA was significantly higher in adenocarcinoma than in the uninvolved lung tissue, whereas no significant difference from the control was observed in other histologic types. The discrepancy between the enzyme activity and immunoreactive content suggested that in the adenocarcinoma of the lung an immunoreactive but enzymatically inactive Mn-SOD protein existed and that a high content of this enzyme was characteristic of lung adenocarcinoma.

Endobronchial polypoid adenocarcinoma of the lung. Histological and ultrastructural studies of five cases.

Abstract: Five cases of adenocarcinomas of the lung with predominantly endobronchial polypoid growth in large bronchi were reported. The histology of these cases was well-differentiated papillary adenocarcinoma, the tumor cells of which were columnar (4/5) and cuboidal (1/5). More than 70% of the volume of each tumor grew in the bronchial lumen with neighboring intraepithelial growth. Ultrastructurally the tumor cells were characterized by numerous mitochondria (5/5), some basal bodies (5/5), poorly developed cilia (1/5), and many dilated smooth endoplasmic reticular near the cell surface (2/5); these are features characteristic of ciliated bronchial epithelial cells. There were some mucus-producing cells (3/5), which might be differentiating toward goblet cells. Membrane-bound secretory granules with an electron-dense core or fingerprint appearance were also found (2/5); these resembled Clara cell granules. The above findings suggested that polypoid adenocarcinoma in large bronchi had the ability to differentiate toward bronchial or bronchiolar surface epithelial cells with or without mucus production.

A calcified adenocarcinoma of the lung with very high CT numbers.

Abstract: A case is reported of a man with a solitary pulmonary nodule that had an average CT number of 366 HU. Biopsy of the lesion demonstrated a primary adenocarcinoma of the lung with diffuse calcification. It is concluded that high CT numbers of solitary nodules do not ensure a benign lesion.

Dose-related induction of lung, thyroid and kidney tumors by N-bis(2-hydroxypropyl)nitrosamine given orally to F344 rats.

Abstract: The organotropic effect of orally administered N-bis(2-hydroxypropyl)nitrosamine (DHPN) in male F344 rats was studied with respect to total dosage and length of observation period. DHPN was given at 5 dosages, a single intragastric intubation of 800 mg/kg body weight, or administration as a 0.2% solution in the drinking water for 4, 7, 14 or 21 days. Animals were killed at weeks 32, 40 and 48. Tumors were induced in the lung, thyroid, kidney and urinary bladder. High tumor incidence was demonstrated in the lung and thyroid. Dose-related increases in overall tumor incidences in these 4 organs were clearly shown but time-related increases at the 3 sacrifice time points were not clear. Histologically, the tumors were adenoma and adenocarcinoma of the lung and thyroid, renal cell tumor, nephroblastoma and transitional cell tumor of the kidney, and transitional cell papilloma of the urinary bladder.

Phase II clinical evaluation of AZQ in adenocarcinoma of the lung.

Abstract: Twenty patients with advanced measurable adenocarcinoma of the lung were treated with AZQ 20 mg/m2 weekly for 4 weeks, followed by a 2-week rest. No complete or partial responses were observed. Stabilization was observed in seven individuals, lasting 6-32+ weeks, with a median of 6 weeks. Toxicity was limited to reversible myelosuppression. We conclude that AZQ administered at this dose and schedule has no significant activity against advanced adenocarcinoma of the lung.

Adenocarcinoma of the Lung in Patients Younger Than 35 Years

Abstract: To the Editor.— The letter by Schacter et al1appears to be based on lung cancer statistics from a cancer registry and patients seen at a medical center. These are at variance with State of Hawaii Tumor Registry statistics and the experience of the Southwest Oncology Group (SWOG). The Table shows that, while not common, lung cancer does occur in young persons. Of the 28 cases of adenocarcinoma in Hawaii, 19 were in men and nine in women, while the seven SWOG patients were three men and four women. The statistics in the Table document the occurrence, albeit uncommon, of lung cancer in young persons (1.3% of cases in Hawaii and 0.8% of SWOG patients). One of the references2cited by Schacter was used tosupport the statement that "adenocarcinoma of the lung is rare in patients younger than 35 years." This study, however, describes 35 patients with