Showing papers on "Anticipation (genetics) published in 1984"

Anticipation of duodenal peptic ulcer. I. Prevention in subjects at risk of inheriting it

Abstract: A total of 267 patients with duodenal ulcer with a familial history of the same disease were studied, whose patients, one of them or both, had suffered from the same disease. It was established that in the children of the affected parents, the disease occurred at a considerably earlier age. The premature occurrence for the separate groups is with 12.5 to 16.7 years on the average and is established in 96,6 per cent of the probands, whereas a retardation was observed in only 1,5%. It could, therefore, be admitted that the anticipation is a regular phenomenon for the duodenal ulcer. Its effect, however, has some specific characteristics in the duodenal ulcer disease, and cannot be explained only from the position of the hypothesis of multigen heredity. The anticipation of ulcerogenesis in the children of the affected parents is admitted to be determined, primarily, by the progressively enhanced action of polygens in the generations. The environmental factors, very likely, play an additional role in that process.