Showing papers on "Antitussive Agent published in 1976"
Journal Article•
TL;DR: Butorphanol was shown to be as effective against cough of pathological origin as against experimentally induced cough in the dog and Naloxone reversed the antitussive effects of butorphanol, codeine, morphine and dl-pentazocine.
Abstract: Butorphanol (levo-N-cyclobutylmethyl-3, 14-dihydroxy morphinan), a potent analgetic agent of the narcotic antagonist type with a low abuse potential in laboratory animals, was evaluated for antitussive activity in unanesthetized guinea-pigs and dogs. Subcutaneously, it was over 100 times more active than codeine, dextromethorphan and dl-pentazocine and about 20 times more active than morphine in the guinea-pig, while in the dog it was 100, 10 and 4 times more active than codeine, dl-pentazocine and morphine, respectively. Orally, butorphanol was 15-20 times more active than either codeine or dextromethrophan in both species. Naloxone reversed the antitussive effects of butorphanol, codeine, morphine and dl-pentazocine while those of dextromethorphan were not antagonized. The antitussive effect of butorphanol and morphine lasted about 4 hr and both compounds were longer acting than codeine. Butorphanol was also shown to be as effective against cough of pathological origin as against experimentally induced cough in the dog.
21 citations
TL;DR: A new method for objective assessment of cough under normal or pathological conditions is described and it is shown that Thoracic coughing can be discriminated from any other pressure wave because of its relatively high frequency.
Abstract: A new method for objective assessment of cough under normal or pathological conditions is described Thoracic coughing can be discriminated from any other pressure wave because of its relatively high frequency This method was applied in a double blind crossover trial in 18 patients with respiratory disease
4 citations