Showing papers on "Aryl radical published in 1984"

Blood-pressure lowering piperazine derivatives

Abstract: The invention relates to new piperazine derivatives of the formula wherein A is an optionally substituted bicyclic hetero aryl radical, n has the value 1 or 2, R, and R 2 are hydrogen or alkyl (1-3 C). A is -CH 2 -CH 2 - or -CH(CH 3 )-CH 2 - and B is an optionally substituted aryl or hetero aryl group, an alkyl group or a saturated or partly unsaturated cycloalkyl group and salts and products thereof. These new compounds are useful for the treatment of circulatory diseases. In particular it has has been found that these compounds have blood-pressure lowering properties regulated by a central mechanism of action. The invention also relates to new intermediates useful for the preparation of piperazine compounds of the above formula (1)

Derivatives of 2-azabicyclo[3.1.0]hexane-3-carboxylic acid, and hypotensive use thereof

Abstract: The invention relates to compounds of the formula I ##STR1## in which n denotes 0 or 1, R denotes hydrogen, alkyl, alkenyl or aralkyl, R1 denotes hydrogen or alkyl, which can optionally be substituted by amino, acylamino or benzoylamino, alkenyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, aryl or partially hydrogenated aryl, each of which can be substituted by alkyl, alkoxy or halogen, aralkyl or aroylalkyl, both of which can be substituted in the aryl radical as defined previously, a monocyclic or bicyclic S- or O- and/or N-heterocyclic radical or a side chain of an aminoacid, R2 denotes hydrogen, alkyl, alkenyl or aralkyl, Y denotes hydrogen or hydroxyl, Z denotes hydrogen, or Y and Z together denote oxygen, X denotes alkyl, alkenyl, cycloalkyl, aryl, which can be monosubstituted, disubstituted or trisubstituted by alkyl, alkoxy, hydroxyl, halogen, nitro, amino, acylamino, alkylamino, dialkylamino and/or methylenedioxy, or 3-indolyl, and to a process for their preparation, agents containing them and and their use, and to 2-azabicyclo[3.1.0]hexane derivatives as intermediates, and a process for their preparation.

Piperazine-substituted aryl and aralkyl carboxylic acids useful for treating infirmaties caused by excess lipids or thrombocyte

Abstract: The present invention is concerned with new carboxylic acid derivatives, with processes for the preparation thereof and with pharmaceutical compositions for lipid depression and thrombocyte aggregation, containing them, and to methods for treating infirmaties caused by excess lipids or thrombocyte aggregation. The new carboxylic acid derivatives according to the present invention are compounds of the general formula: ##STR1## wherein A is a valency bond or a lower alkylene chain, B is a valency bond or a saturated or unsaturated lower alkylene chain, R is hydrogen, an alkyl group which can be substituted by hydroxyl, carboxyl, sulphonic acid or optionally substituted phenoxy group, or R is an aralkyl radical, the aryl moiety of which can be substituted and the alkyl moiety of which is optionally unsaturated and can contain up to 4 carbon atoms, or R is a phenacyl radical, the phenyl moiety optionally substituted, or R is an acyl radical derived from aliphatic, araliphatic or aromatic carboxylic or sulphonic acid, or R is an aryl radical optionally substituted with the proviso that when A is a valency bond, R cannot be hydrogen, methyl, ethyl, hydroxyethyl, benzyl or phenyl, and the physiologically acceptable salts, esters and amides thereof.

Fungicidal agent, substituted glucopyranosyl amine and a method of combating moulds

Abstract: The fungicidal agent contains an inert carrier and a compound of the general formula in which R and R are hydrogen, a substituted alkyl or alkenyl radical, an optionally substituted cycloalkyl radical, an optionally substituted aralkyl radical and an optionally substituted aryl radical, and, furthermore, R and R can be members of a common 5- or 6-membered ring which may contain further hetero atoms, and D-glucopyranosyl-1-amines.

Derivatives of omega mercaptopropanamides, and their homologues, process for their preparation, their use as medicines, compositions containing them and intermediates obtained

Abstract: For the Contracting States : BE CH DE FR GB IT LI LU NL SE 1. Compounds with the formula (I) : see diagramm : EP0115997,P26,F1 in which R1 represents a hydrogen atom or a see diagramm : EP0115997,P26,F2 radical, R'1 being an alkyl radical containing from 1 to 5 carbon atoms or an aryl radical possibly substituted by a hydroxy radical, an alkyl radical containing from 1 to 5 carbon atoms, an alkoxy radical containing from 1 to 5 carbon atoms, a nitro radical or a halogen atom, n represents a whole number able to vary from 1 to 5, R2 represents a hydrogen atom, an alkyl radical containing from 1 to 5 carbon atoms, an aryl or arylalkyl radical containing from 6 to 15 carbon atoms, possibly substituted by an alkyl radical containing from 1 to 5 carbon atoms, an alkoxy radical containing from 1 to 5 carbon atoms, a hydroxyl radical, a halogen atom or a trifluoromethyl radical, R3 represents a heterocyclic radical chosen from the following radicals :- thiazolyl, 4,5-dihydrothiazolyl, pyridinyl, oxazolyl, isoxazolyl, imidazolyl, pyrimidyl, tetrazolyl, benzimidazolyl, benzothiazolyl or benzoxazolyl, possibly substituted by an alkyl radical containing from 1 to 5 carbon atoms or R3 represents a hydrogen atom, a phenyl radical possibly substituted by one or more radicals chosen from the group constituted by alkyl radicals containing from 1 to 5 carbon atoms, alkoxy radicals containing from 1 to 5 carbon atoms, a hydroxyl radical, a nitro radical, halogen atoms, a trifluoromethyl radical, a carboxymethyl radical, alkoxy carbonylmethyl radicals in which the alkoxy radical contains from 1 to 5 carbon atoms, aralkyloxy radicals containing from 7 to 15 carbon atoms and the radicals : see diagramm : EP0115997,P27,F3 in which X and X', identical or different, represent a hydrogen atom or an alkyl radical containing from 1 to 5 carbon atoms, R3 however not being able to represent a phenyl radical, not substituted or substituted by one or more radicals chosen from the group constituted by alkyl radicals containing from 1 to 5 carbon atoms, alkoxy radicals containing from 1 to 5 carbon atoms, and halogen atoms, when R2 represents a hydrogen atom and when n is equal to 1 or 2, and R3 not being able to represent a phenyl radical substituted by a carboxymethyl radical when R2 represents a methyl radical and when n is equal to 1, as well as their addition salts with acids and bases. For the Contracting State : AT 1. Process for preparing compounds with the formula (I) : see diagramm : EP0115997,P28,F1 in which R1 represents a hydrogen atom or a see diagramm : EP0115997,P28,F2 radical, R'1 being an alkyl radical containing from 1 to 5 carbon atoms or an aryl radical possibly substituted by a hydroxy radical, an alkyl radical containing from 1 to 5 carbon atoms, an alkoxy radical containing from 1 to 5 carbon atoms, a nitro radical or a halogen atom, n represents a whole number able to vary from 1 to 5, R2 represents a hydrogen atom, an alkyl radical containing from 1 to 5 carbon atoms, an aryl or arylalkyl radical containing from 6 to 15 carbon atoms, possibly substituted by an alkyl radical containing from 1 to 5 carbon atoms, an alkoxy radical containing from 1 to 5 carbon atoms, a hydroxyl radical, a halogen atom or a trifluoromethyl radical, R3 represents a heterocyclic radical chosen from the following radicals :- thiazolyl, 4,5-dihydrothiazolyl, pyridinyl, oxazolyl, isoxazolyl, imidazolyl, pyrimidyl, tetrazolyl, benzimidazolyl, benzothiazolyl or benzoxazolyl, possibly substituted by an alkyl radical containing from 1 to 5 carbon atoms or R3 represents a hydrogen atom, a phenyl radical possibly substituted by one or more radicals chosen from the group constituted by alkyl radicals containing from 1 to 5 carbon atoms, alkoxy radicals containing from 1 to 5 carbon atoms, a hydroxyl radical, a nitro radical, halogen atoms, a trifluoromethyl radical, a carboxymethyl radical, alkoxy carbonylmethyl radicals in which the alkoxy radical contains from 1 to 5 carbon atoms, aralkyloxy radicals containing from 7 to 15 carbon atoms and the radicals : see diagramm : EP0115997,P29,F3 in which X and X', identical or different, represent a hydrogen atom or an alkyl radical containing from 1 to 5 carbon atoms, R3 however not being able to represent a phenyl radical, not substituted or substituted by one or more radicals chosen from the group constituted by alkyl radicals containing from 1 to 5 carbon atoms, alkoxy radicals containing from 1 to 5 carbon atoms, and halogen atoms, when R2 represents a hydrogen atom and when n is equal to 1 or 2, and R3 not being able to represent a phenyl radical substituted by a carboxymethyl radical when R2 represents a methyl radical and when n is equal to 1, as well as their addition salts with acids and bases, characterized in that : - to prepare compounds with the formula (I) in which R1 , R2 and R3 have the previously given significance and in which n=1, as well as their addition salts with acids and bases, and acid with the formula (II) : see diagramm : EP0115997,P29,F4 in which R'1 and R2 have the significances already indicated, or a functional derivative of this acid, is submitted to the action of a product with the formula (III) : H2 N-R3 in which R3 has the significance already indicated, so as to obtain a product with the formula (I) in which : see diagramm : EP0115997,P29,F5 R'1 as well as R2 and R3 have the significances already indicated and in which n=1, which product with the formula (I), if necessary or desired, is saponified, so as to obtain a product with the formula (I) in which R1 represents a hydrogen atom, which products with the formula (I) are submitted, if desired, to the action of a base or an acid so as to form the corresponding salts ; - to prepare compounds with the formula (I) in which R1 , R2 and R3 have the previously given significance and in which n is a whole number varying from 1 to 5, as well as their addition salts with acids and bases, an acid with the formula (IV) : see diagramm : EP0115997,P29,F6 in which X1 is a halogen atom and in which n and R2 have the significances given above, or a functional derivative of this acid, is submitted to the action of a product with the previous formula (III) (NH2 -R3 ), so as to obtain a product with the formula (V) : see diagramm : EP0115997,P29,F7 in which X1 , n, R2 and R3 have the previosu significances, which is submitted to the action of the anion of a thioacid with the formula (VI) : see diagramm : EP0115997,P30,F8 in which R'1 keeps its significance, so as to obtain a product with the formula (I) in which r1 = R'1 see diagramm : EP0115997,P30,F9 n represents a whole number able to vary from 1 to 5 and in which R'1 , R2 and R3 have the significances given above, which product with the formula (I), if necessary or desired, is saponified, so as to obtain a product with the formula (I) in which R1 represents a hydrogen atom, which products with the formula (I) are submitted, if desired, to the action of an acid or of a base so as to form the corresponding salts.

Process for the production of triaryl methane compounds

Abstract: A process for the production of a compound of formula ##STR1## which comprises reacting a compound of formula ##STR2## or a mixture of the compounds (2a) and (2b) with a compound ZH or a compound of formula ##STR3## or a mixture of the compounds (2c) and (2d) with a compound YH, both reactions under acidic conditions, wherein X and Y are the same or different and each represents an aromatic carbocyclic radical having an unsubstituted or substituted amino group in the para position to the indicated bond, or a heterocyclic group, and Z represents an aryl radical of formula ##STR4## wherein R1 and R2 independently of one another represent hydrogen, C1 -C12 alkyl, C2 -C8 -alkoxyalkyl, cycloalkyl, aralkyl, aryl, or substituted alkyl, cycloalkyl, aralkyl or aryl, or R1 and R2 together with the nitrogen atom which links them represent a five- or six-membered, preferably saturated, heterocyclic radical and W represents hydroxy, alkoxy, aryloxy, amino or substituted amino, and the aromatic carbocyclic radical of formula (1a) or (1b) may be further substituted by one or more halogen, cyano, nitro, alkyl of 1 to 4 carbon atoms or alkoxy of 1 to 4 carbon atoms, V represents oxygen, sulphur or imino and T1 and T2 independently represent hydrogen, C1 -C12 -alkyl, C2 -C12 -alkenyl, aryl, aralkyl, and T1 also amido or ureido, or T1 and T2 together with the nitrogen atom which links them represent a five- or six-membered heterocyclic radical.

Fused imidazole compounds, processes for the preparation thereof and pharmaceutical compositions containing them

Abstract: The present invention provides new fused imidazole compounds of the formula: wherein A is a lower alkylene radical, R' is a hydrogen or halogen atom or a lower alkyl or lower alkoxy radical, R 2 is a hydrogen atom or a lower alkyl, cyclo(lower)alkyl, pyridyl, ar(lower)alkyl, which may be substituted by halogen, or aryl radical, which may be substituted by lower alkyl, lower alkoxy, hydroxy or halogen, R 3 is an N-containing unsaturated heterocyclic radical, which may be substituted by lower alkyl or amino, and Y is =C- or =N-, and the pharmaceutically-acceptable salts thereof; and processes for the preparation thereof, as well as pharmaceutical compositions comprising them. These new compounds and the salts thereof are useful as anti-ulcer agents.

N-substituted phenothiazine derivative as a catalyst for the nuclear chlorination of aromatic hydrocarbons

Abstract: 1. Catalyst system based on a Lewis acid for the ring chlorination of aromatic hydrocarbons, characterized in that it contains an N-substituted phenothiazine derivative of formula : see diagramm : EP0126669,P6,F4 in which R denotes either see diagramm : EP0126669,P6,F1 with R1 denoting : =O, =S, see diagramm : EP0126669,P6,F2 see diagramm : EP0126669,P6,F3 X being the halogen Br or Cl, and R2 denoting an aryl radical, the halogen Br or Cl, or the radical -CHx Xy in which X is the halogen Br or Cl with x = 0 to 2, y = 1 to 3 and x + y = 3 or an aryl radical.

Spirocyclic aminoacid derivatives, processes for their preparation, agents containing them and their use and new spirocyclic aminoacids as intermediates and processes for their preparation

Abstract: The invention relates to new spirocyclic aminoacid derivatives of the formula I ##STR1## in which m denotes 1 or 2, n denotes 0 or 1, R denotes hydrogen, alkyl or aralkyl, R1 denotes hydrogen or alkyl which can be optionally substituted by amino, acylamino or benzoylamino, alkenyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, aryl or partially hydrogenated aryl, each of which can be substituted by alkyl, alkoxy or halogen, arylalkyl or aroylalkyl, both of which can be substituted as defined above in the aryl radical, an S- or O- and/or N-heterocyclic radical or a side chain of an α-aminoacid, R2 denotes hydrogen, alkyl, alkenyl or aralkyl, Y denotes hydrogen or hydroxyl, Z denotes hydrogen, or Y and Z together denote oxygen and X denotes alkyl, alkenyl, cycloalkyl, aryl, which can be monosubstituted, disubstituted or trisubstituted by alkyl, alkoxy, hydroxyl, halogen, nitro, amino, alkylamino, dialkylamino and/or methylenedioxy, or 3-indolyl, processes for their preparation, agents containing them and their use and new spirocyclic aminoacids as intermediates and a process for their preparation.

Heat-developable image-pattern recording material

Abstract: A composition suitable for application as a layer on a heat-developable image-pattern recording material to enhance the developability and stability thereof, comprising a silver salt of a benzotriazole, a reducing agent, a binder, at least one compound having the following Formula [I]: ##STR1## wherein R1 represents a hydrogen, an amino radical, or a substituted or unsubstituted alkyl, alkenyl or aryl radical; R2 represents a hydrogen, an amino alkyl, alkenyl or aryl radical is disclosed. The disclosed composition has improved developability.

Process for the preparation of polyoxyalkylene ethers

Abstract: A process for the preparation of polyoxyalkylene ethers of the formula R1O-[CnH2nO-]xM in which R1 is an alkyl radical with 1 to 4 carbon atoms, an alkylene radical, an aryl radical or an alkaryl radical, M is an alkali cation, n is any number from 2 to 3, and x is a whole number, by the stoichiometric polymerization of alkylene oxides or their mixtures having the general formula CnH2nO on alkali alcoholate mixtures, composed of 1 to 20 mole percent of potassium alcoholate and 99 to 80 mole percent of sodium alcoholate. Compared to the use of sodium alcoholate alone, the addition reaction proceeds uniformly at temperatures as low as 80 DEG to 100 DEG C. and the initial delay at the start of the reaction is avoided. Even so, it is possible to keep the isomerization of propylene oxide to allyl alcohol within limits. Products are obtained with a relatively narrow molecular weight distribution and a low double bond content.

3-amino-2-oxo-azetidine derivatives containing in position 1 a nitrogen heterocyclic radical, process for their preparation, their use as therapeutical agents and intermediates for their preparation

Abstract: 1. Claims : For the contracting states : BE, SE, CH, DE, FR, GB, IT, LI, LU, NL Products of general formula (I) : see diagramm : EP0114128,P43,F6 in which R represents a hydrogen atom, an alkyl, alkenyl or alkynyl radical having at the most 12 carbon atoms, optionally substituted by one or more radicals chosen from carboxy radicals, optionally salified or esterified ; amino, methylamino, dimethylamino and diethylamino radicals ; the phenyl radical optionally substituted by one or more radicals chosen from the following radicals : hydroxy, methyl, methoxy, chloro, bromo, fluoro ; fluoro, chloro, bromo or iodo radicals ; nitrile, CONH2 or CONH SO2 R" radicals in which R" represents an alkyl radical having from 1 to 4 carbon atoms ; a phenyl radical, an amino, methyl or dimethylamino radical ; a heterocyclic amino radical chosen from piperidino, morpholino piperazino or 4-ethyl-2,3-dioxo-1-piperazino radicals ; - a cycloalkyl radical having from 3 to 8 carbon atoms or a radical : see diagramm : EP0114128,P44,F1 salified or esterified, in which nc represents a whole number from 0 to 5, - one of the following radicals : acetyl, propionyl or benzoyl, carbamoyl, dimethylamino carbonyl, phenyl or benzyl optionally substituted by alkyl, alkoxy or halogen ; R1 represents a hydrogen atom, an alkyl, alkenyl, alkynyl or thioalkyl radical having a the most 12 carbon atoms, optionally substituted by one or more radicals chosen from azido or alkylthio radicals having from 1 to 4 carbon atoms or a phenylthio radical, optionally salified or esterified carboxy radicals, amino, methylamino, dimethylamino or diethylamino radicals, the phenyl radical, optionally substituted by one or more radicals chosen from hydroxy, halogeno, trifluoromethyl, amino, alkyl or alkoxy radicals having from 1 to 4 carbon atoms ; fluoro, chloro, bromo or iodo radicals, nitrile, CONH2 or CONH SO2 R" radicals in which R" represents an alkyl radical having from 1 to 4 carbon atoms, a phenyl radical, an amino, methyl or dimethylamino radical, a heterocyclic amino radical chosen from piperidino, morpholino, piperazino or 4-ethyl-2,3-dioxo-1-piperazino radicals ; a heterocyclic aryl radical chosen from the following radicals : thienyl, furyl, pyrannyl, thiazolyl, thiadiazolyl, oxazolyl, oxadiazolyl, pyridinyl or pyrimidinyl ; and the following radicals : acetoxy, propionyloxy, benzoyloxy, acetylamino, benzylcarbonyl, carbamoyloxy, methylaminocarbonyloxy or dimethylaminocarbonyloxy, acetyl, propionyl, and benzoyl, - a free, esterified or salified carboxy radical, - a phenyl radical optionally substituted by one of the following radicals : alkyl, trifluoromethyl, alkoxy, alkylthio, halogen, hydroxyl, amino or hydroxylakyl, a heterocyclic radical chosen from the following radicals : thienyl, furyl, pyrrolyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, imidazolinyl, imidazolyl, triazolyl, tetrazolyl, thiadiazolyl, oxadiazolyl, pyridinyl, pyrimidinyl, pyridazinyl, triazinyl optionally substituted by an alkyl, carboxy, carboxy alkyl, aminoalkyl or dialkylaminoalkyl radical, - an acetyl, propionyl, n-butyryl or benzoyl radical, optionally substituted by alkoxy or hydroxy, - a carbamoyl, methyl or dimethylcarbamoyl radical, - a azido radical. R2 represents a nitrogen-containing heterocycle optionally substituted by one or more of the radicals chosen from the group formed by the following radicals : nitro, carboxy, CF3 , nitrile, halogen, sulpho, alkylsulpho, (CH2 )n SO3 H, (CH2 )n NHSO3 H, (CH2 )n SO2 NH2 , (CH2 )n CO2 H, in which n represents a whole number from 1 to 4 and containing at least one acid hydrogen, X represents a CH radical or a nitrogen atom, the wavy lines indicate that the OR radical can exist in cis or trans form or in the form of a cis-trans mixture, the products of formula (I) being in racemic or optically active form, as well as the salts of the products of formula (I) withthe bases and acids. 1. Claims : For the contracting state AT Process for preparing the products of general formula (I) : see diagramm : EP0114128,P48,F3 in which R represents a hydrogen atom, an alkyl, alkenyl or alkynyl radical having at the most 12 carbon atoms, optionally substituted by one or more radicals chosen from carboxy radicals, optionally salified or esterified ; amino, methylamino, dimethylamino and diethylamino radicals ; the phenyl radical optionally substituted by one or more radicals chosen from the following radicals : hydroxy, methyl, methoxy, chloro, bromo, fluoro ; fluoro, chloro, bromo or iodo radicals ; nitrile, CONH2 or CONH SO2 R" raidcals in which R" represents an alkyl radical having from 1 to 4 carbon atoms ; a phenyl radical ; an amino, methyl or dimethylamino radical ; a heterocyclic amino radical chosen from piperidino, morpholino piperazino or 4-ethyl-2,3-dioxo-1-piperazino radicals ; - a cycloalkyl radical having from 3 to 8 carbon atoms or a radical : see diagramm : EP0114128,P48,F1 salified or esterified, in which nc represents a whole number from 0 to 5, - one of the following radicals : acetyl, propionyl, or benzoyl, carbamoyl, dimethylamino carbonyl, phenyl or benzyl optionally substituted by alkyl, alkoxy or halogen ; R1 represents a hydrogen atom, an alkyl, alkenyl, alkynyl or thioalkyl radical having at the most 12 carbon atoms, optionally substituted by one or more radicals chosen from azido or alkylthio radicals having from 1 to 4 carbon atoms or a phenylthio radical, optionally salified or esterified carboxy radicals, amino, methylamino, dimethylamino or diethylamino radicals, the phenyl radical, optionally substituted by one or more radicals chosen from hydroxy, halogeno, trifluoromethyl, amino, alkyl or alkoxy radicals having from 1 to 4 carbon atoms ; fluoro, chloro, bromo or iodo radicals, nitrile, CONH2 or CONH SO2 R" which R" represents an alkyl radical having from 1 to 4 carbon atoms, a phenyl radical, an amino, methyl or dimethylamino radical, a heterocyclic amino radical chosen from piperidino, morpholino, piperazino or 4-ethyl-2,3-dioxo-1-piperazino radicals ; a heterocyclic aryl radical chosen from the following radicals : thienyl, furyl, pyrannyl, thiazolyl, thiadiazolyl, oxazolyl, oxadiazolyl, pyridinyl or pyrimidinyl ; and the following radicals : acetoxy, propionyloxy, benzoyloxy, acetylamino, benzylcarbonyl, carbamoyloxy, methylaminocarbonyloxy or dimethylaminocarbonyloxy, acetyl, propionyl, and benzoyl, - a free, esterified or salified carboxy radical, - a phenyl radical optionally substituted by one of the following radicals : alkyl, trifluoromethyl, alkoxy, alkylthio, halogen, hydroxyl, amino or hydroxyalkyl, a heterocyclic radical chosen from the following radicals : thienyl, furyl, pyrolyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, imidazolinyl, imidazolyl, triazolyl, tetrazolyl, thiadiazolyl, oxadiazolyl, pyridinyl, pyrimidinyl, pyridazinyl, triazinyl optionally substituted by an alkyl, carboxy, carboxy alkyl, aminoalkyl or dialkylaminoalkyl radical, - an acetyl, propionyl, n-butyryl or benzoyl radical, optionally substituted by alkoxy or hydroxy, - a carbamoyl, methyl or dimethylcarbamoyl radical, - an azido radical. R2 represents a nitrogen-containing heterocycle optionally substituted by one or more of the radicals chosen from the group formed by the following radicals : nitro, carboxy, CF3 , nitrile, halogen, sulpho, alkylsulpho, (CH2 )n SO3 H, (CH2 )n NHSO3 H, (CH2 )n SO2 NH2 , (CH2 )n CO2 H, in which n represents a whole number from 1 to 4 and containing at least one acid hydrogen, X represents a CH radical or a nitrogen atom, the wavy lines indicate that the OR radical can exist in cis or trans form or in the form of a cis-trans mixture, the products of formula (I) being in racemic or optically active form, as well as the salts of the products of formula (I) with the acids and bases, characterized in that a product of formula (II) : see diagramm : EP0114128,P49,F1 cis or trans, racemic or optically active, in which formula either R1 p represents R1 , R1 having the previously indicated significance, or R1 p represents the substituent R1 in which the reactive functions are protected and either R2 p represents R2 , R2 having the previously indicated significance, or R2 p represents the substituent R2 in which the reactive functions are protected, is treated with a product of formula (III) : see diagramm : EP0114128,P49,F3 syn or anti, in which Rb represents a hydrogen atom or a protector group of the amino radical and Rp represents a protector group of the hydroxyl radical or Rp represents R, R having the significance indicated in claim 1, or Rp represents a radical R in which the reactive functions are protected, so as to obtain a product of formula (IV) : see diagramm : EP0114128,P49,F5 syn or anti, racemic or optically active, in which Rp, R1 p, R2 p and Rb have the previous significance, which product is submitted, if necessary and if desired, to any one of the following reactions, in any order : a) cleavage by hydrolysis, hydrogenolysis or by the action of the thiourea of the protector group or groups which can be represented by Rb and Rp or can be contained in Rp, R1 p and R2 p ; b) esterification or salification of the carboxy or sulpho radicals which can be contained in the radicals Rp, R1 p and R2 p ; c) salification by an acid of the amino radical or radicals ; d) resolution of the molecule so as to obtain an optically active product.

Fungicidal azole compounds, their preparation and use

Abstract: Azole compound of the formula I, in which Rn represents up to 5 identical or different substituents selected from the group comprising halogen, alkyl, alkoxy, alkylthio, alkylsulphonyl, haloalkyl, nitro, cyano, optionally substituted phenyl, optionally substituted phenoxy or hydrogen, R represents an optionally branched alkyl radical, a cycloalkyl radical, a cycloalkylalkyl radical, an optionally substituted aryl radical, an optionally substituted aralkyl radical, an optionally substituted aryloxyalkyl radical, an optionally substituted benzyloxyalkyl radical, an optionally substituted alkenyl radical or an optionally substituted alkynyl radical, R and R independently of one another represent alkyl or together represent a di-radical of the formula -(CH2)m- where m represents an integer from 2 to 7, Az represents 1-(1,2,4-triazolyl), 4-(1,2,4-triazolyl), 1-imidazolyl, 1-pyrazolyl or 1-benzimidazolyl, where R represents hydrogen, C1- to C4-alkyl, vinyl or allyl and R represents hydrogen, C1- to C3-alkyl, optionally substituted alkenyl, optionally substituted alkynyl or optionally substituted benzyl, the biologically acceptable salts or complex compounds of the compounds of the formula I, a process and a specific process for the preparation of compounds of the formula I, and their use in fungicidal crop protection agents.

Process for the preparation of fluoralkyl-substituted alkanes or alkenes

Abstract: 1. A process for preparing fluoroalkyl-substituted alkanes or alkenes by reacting a compound of the following formula XRf Z in which Rf denotes a perfluorinated alkylene radical, which is straight-chain and has 1 to 15 carbon atoms or is branched and has 3 to 15 carbon atoms or is cyclic and has 4 to 8 carbon atoms, X denotes hydrogen, fluorine, chlorine, bromine or iodine, and Z denotes bromine or iodine, with a compound of the following formulas see diagramm : EP0142041,P7,F1 in which R1 and R2 can be identical or different and each denotes : hydrogen, fluorine, chlorine, a perfluoroalkyl radical which has 1 to 12 carbon atoms and in which a fluorine atom can be replaced by hydrogen or chlorine, an alkyl radical having 1 to 20 carbon atoms, an alkenyl radical having 2 to 20 carbon atoms, an aryl radical having 6 to 10 carbon atoms or an arylalkyl radical having 7 to 12 carbon atoms, and a substituent of the last mentioned four tyeps, can in turn be substituted by F, CI, -OH or -OR', in which R' denotes an alkyl or alkylcarboxyl radical having 1 to 5 carbon atoms, or CH-=C-R3 in which R3 denotes : a perfluoroalkyl radical of 1 to 12 carbon atoms in which a fluorine atom can be replaced by a hydrogen or chlorine atom, an alkyl radical of 1 to 20 carbon atoms, an alkenyl radical of 2 to 20 carbon atoms, an aryl radical of 6 to 10 carbon atoms or an arylalkyl radical of 7 to 12 carbon atoms and a substituent of the last mentioned four types can in turn be substituted by F, CI, -OH or -OR', in which R' denotes an alkyl or alkylcarboxyl radical of 1 to 5 carbon atoms, under heat and under atmospheric pressure or superatmospheric pressure in the presence of a metal complex catalyst, characterized by carrying out the process at 20 to 130 degrees C and using as said catalyst at least one metal complex compound which contains as the central atom a metal which, in the periodic table of the elements, has one of the atomic numbers 24 to 30, 42 to 48 or 74 to 79 and has an oxidation state of zero, +1 or +2, and contains at least one of the following ligands : carbon monoxide, trialkyl phosphite, triaryl phosphite or a compound of the formula (R)3 Q in which R denotes an alkyl, aryl or arylalkyl radical and Q denotes phosphorus, arsenic or antimony, the metal complex compounds which contain carbon monoxide as ligand and a metal which, in the periodic table of elements, has one of the atomic numbers 26 to 28, 44 to 46, and 76 to 78 are disclaimed.

Simultaneous preparation of nitriles and acrylamide or methacrylamide

Abstract: Nitriles of the general formula I R.sup.1 --CN (I) where R 1 is a saturated or unsaturated, straight-chain, branched or cyclic alkyl radical, an aralkyl radical or an aryl radical, each of which is of not more than 20 carbon atoms and can be unsubstituted or further substituted, and (meth)acrylamide are prepared simultaneously by a process in which an aldoxime of the general formula III R.sup.1 --CH═NOH (III) where R 1 has the above meanings, is heated at from 50° to 180° C. in the presence of a copper(II) carboxylate and of (meth)acrylonitrile.

Phosphorylated glycosyl-amides, -ureas, -carbamates and -thiocarbamates and method of use

Abstract: Compounds of the formula ##STR1## in which R 1 represents an optionally substituted, straight-chain or branched, saturated, monounsaturated or polyunsaturated alkyl radical, an optionally substituted, saturated or one- or polyunsaturated cycloalkyl radical or an optionally substituted aryl radical or aralkyl radical, X represents CH 2 , O, S, NH or N-alkyl with up to 20 C atoms, R 2 has the meaning of R 1 , and can represent hydrogen if X denotes CH 2 , the radicals R 3 independently of one another represent hydrogen, an acyl radical or alkyl radical with in each case up to 20 C atoms, a silyl radical and/or a phosphoric acid or phosphoric acid ester radical and R 4 denotes hydrogen, methyl or --CH 2 --OR 3 , with the proviso that one of the radicals R 3 always represents a phosphoric acid or phosphoric acid ester radical, which stimulate a patient's immune system and are thereby effective in combating viral disease and bacterial infection.

Cationic thiadiazolyl triazene dyestuffs

Abstract: The cationic triazene dyestuffs of the general formula ##STR1## wherein B denotes alkylmercapto, arylmercapto or a radical of the formula ##STR2## R denotes hydrogen or an alkyl, alkenyl, acyl, cycloalkyl, aryl, aralkyl, amino, alkylamino, dialkylamino, arylamino, aralkylamino or heterocyclic radical and R1 denotes hydrogen or an alkyl, alkenyl or aralkyl radical, or R and R1 are bonded to a heterocyclic structure, R2 and R3 denote an alkyl, alkenyl, alkinyl or aralkyl radical, or one of the radicals R2 or R3 also denotes hydrogen, or R3 is bonded to the o-position of A, A denotes an aryl radical and An(-) denotes an anion,and wherein the cyclic and acyclic radicals can contain non-ionic substituents and/or a carboxyl group, can be used for dyeing and printing natural and synthetic materials.

Asymmetrical 1:2 chromium complex dyes

Abstract: 1. A 1 : 2 chromium complex dye of the formula I see diagramm : EP0148121,P29,F2 which has 2 to 7 groups of the formula -SO3 (cation) Ka (anion), and wherein A is the radical of a diazo component of the benzene or naphthalene series, which carries the hydroxyl or carboxyl group in the o-position with respect to the azo group, B is the radical of a coupling component which carries the group X in the position adjacent to the azo group, X is oxygen, or a radical of the formula -NR-, in which R is hydrogen or C1 -C4 alkyl, Ar is an unsubstituted or substituted aryl radical which carries at least two sulfo groups, m is 0 or 1 and Ka (anion) is a cation, where the ring D can carry further substituents, with the proviso that a nitro group is not situated in the 5-position of the 1-hydroxy-2-aminobenzene radical D.

Cationic triazene dyes and their use

Abstract: not available for EP0053751Abstract of corresponding document: US4432897The cationic triazene dyestuffs of the general formula (I) wherein B denotes alkylmercapto, arylmercapto or a radical of the formula R denotes hydrogen or an alkyl, alkenyl, acyl, cycloalkyl, aryl, aralkyl, amino, alkylamino, dialkylamino, arylamino, aralkylamino or heterocyclic radical and R1 denotes hydrogen or an alkyl, alkenyl or aralkyl radical, or R and R1 are bonded to a heterocyclic structure, R2 and R3 denote an alkyl, alkenyl, alkinyl or aralkyl radical, or one of the radicals R2 or R3 also denotes hydrogen, or R3 is bonded to the o-position of A, A denotes an aryl radical and An(-) denotes an anion, and wherein the cyclic and acyclic radicals can contain non-ionic substituents and/or a carboxyl group, can be used for dyeing and printing natural and synthetic materials.

Process for preparing substituted 2,3-dihydrobenzofuran

Abstract: Preparation of substituted 2,3-dihydrobenzofuran which can be defined by the general formula: wherein; Ra is hydrogen, halogen, or an alkyl radical, straight lined or branched containing from 1 to 4 carbon atoms, aryl, alkaryl, -OH, -OR 3 , -N(Ra)2, (Rabeing, in its turn, an alkyl' radical, straight lined or branched containing from 1 to 4 carbon atoms); R b is an alkyl radical, straight lined or branched containing from 1 to 6 carbon atoms, aryl or alkaryl; Rc is hydrogen or has the same meaning as R b ; by rearrangement of 1,1-bis(2-hydroxybenzene)alkyl and/or aryl-ethane, which can be defined by the general formula: wherein Ra, R b and Rc have the above specified meanings, working in the presence of catalytic amounts of at least a mineral or an organic acidic compound, at a high temperature and withdrawing from the reaction mass the products of the rearrangement reactions they are being formed. The 1,1-bis(2-hydroxybenzene)alkyl and/or arylethane are obtained starting from substituted phenols and aldehydes under the influence of specially provided catalysts. Within the scope of this reaction, 1,1-bis(2,3-dihydroxybenzene)alkyl or aryl-methane are found, which can be defined by the general formula: wherein: R is an alkyl radical, straight lined or branched, containing from 1 to 20 carbon atoms, or an aryl radical; R 1 , R 2 and R 3 are equal to or different from each other and represent: H, halogen, or the alkyl radical, straight lined or branched, containing from 1 to 4 carbon atoms, aryl, alkaryl, -OH, -OR 4 ,-N(R 4 ) 2 , R 4 being an alkyl radical, straight lined or branched. containing from 1 to 4 carbon atoms. Such compounds are obtained by reaction of a biphenol which can be defined by the general formula: with an aldehyde which can be defined by the general formula wherein R, R,, R 2 and R 3 have the meanings specified hereinabove, working in the presanca of catalytic amounts of at least one compound, which is a member selected from the group consisting of oxides, hydroxides, alcoholates and carboxylates of the metals belonging to the IA, IIA, IIB and VIIB of the Periodic System of the Eiements, in the presence, or not, of a liquid and inert (i.e. nonreactive) organic solvent, the water being fowned as a reaction byproduct being optionally withdrawn as it is formed.

Bicyclic aminoacids as intermediates

Abstract: Disclosed are cis, exo- and trans-compounds of the formula I ##STR1## in which n denotes 0,1 or 2, R1 denotes hydrogen, (C1 -C6)-alkyl which can optionally by substituted by amino, (C1 -C4)-acyl- or bezoylamino, (C2 -C6)-alkenyl, (C5 -C9)-cycloalkyl, (C5 -C9)-cycloalkenyl, (C5 -C7)-cycloalkyl-(C1 -C4)-alkyl, aryl or partially hydrogenated aryl, which can, in each case, be substituted by (C1 -C2)-alkyl, (C2 -C2)-alkoxy or halogen, aryl-(C1 -C4)-alkyl, /which can be substituted as defined previously in the aryl radical/, a monocyclic or bicyclic sulfur or nitrogen and/or nitrogen heterocyclic radical, or a side chain of naturally occurring aminoacid, R2 denotes hydrogen, (C1 -C6)-alkyl, (C2 -C6)-alkenyl or aryl-(C1 -C4)-alkyl, Y denotes hydrogen or hydroxyl, Z denotes hydrogen or Y and Z together denote oxygen, X denotes (C1 -C6)-alkyl, (C2 -C6)-alkenyl, (C5 -C9)-cycloalkyl or aryl which can be mono-, di- or tri- substituted by (C1 - C4)-alkyl, (C1 -C4)-alkoxy, hydroxyl, halogen, nitro, amino, (C1 -C4)-alkylamino, di-(C1 -C4)-alkylamino or methylenedioxy, or indol-3-yl, or physiologically acceptable salts thereof, a process for the preparation thereof, agents containing them, their use as a medicine and intermediates for the preparation thereof.

2-azabicyclo 2.2.2. octane-3-carboxylic acid derivatives

Abstract: The novel derivatives have the formula I in which n denotes 0 or 2, R denotes hydrogen, alkyl or aralkyl, R denotes hydrogen or unsubstituted or amino-, acylamino- or benzoylamino-substituted alkyl, alkenyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, aryl or partially hydrogenated aryl, each of which can be substituted by alkyl, alkoxy or halogen, aralkyl or aroylalkyl, both of which, as defined above, can be substituted in the aryl radical, an S- or O- and/or N-heterocyclic radical or a side chain of an amino acid, R denotes hydrogen, alkyl, alkenyl or aralkyl, Y denotes hydrogen or hydroxyl, Z denotes hydrogen or Y and Z together denote oxygen and X denotes alkyl, alkenyl, cycloalkyl, aryl, which can be mono-, di- or trisubstituted by alkyl, alkoxy, hydroxyl, halogen, nitro, amino, alkylamino, dialkylamino and/or methylenedioxy or denotes 3-indolyl.

Piperazine derivative, manufacture and hypotensive composition

Abstract: The invention relates to new piperazine derivatives of the formula … … wherein A is an optionally substituted bicyclic hetero aryl radical, n has the value 1 or 2, R1 and R2 are hydrogen or alkyl (1-3C).… A is -CH2-CH2- or -CH(CH3)-CH2- and B is an optionally substituted aryl or hetero aryl group, an alkyl group or a saturated or partly unsaturated cycloalkyl group and salts and products thereof. These new compounds are useful for the treatment of circulatory diseases. In particular it has has been found that these compounds have blood-pressure lowering properties regulated by a central mechanism of action. … The invention also relates to new intermediates useful for the preparation of piperazine compounds of the above formula (1).

Azo dyestuffs having sulpho ortho to azo bridge and containing two triazine reactive groups

Abstract: Reactive azo dyestuffs of the formula ##STR1## wherein D . . . radical of the benzene or naphthalene series, having a sulpho group in the o-position to the azo bridge, K . . . radical of a coupling component of the benzene, naphthalene, pyridone, pyrazolone or hydroxynaphthalene series, or an aryl-azo-aryl radical, R . . . hydrogen or C 1 -C 4 -alkyl, Y . . . OR 1 or SR 1 , R 1 representing an optionally substituted alkyl, aryl or heteroaryl radical, or NR 2 R 3 , R 2 representing hydrogen or an optionally substituted alkyl radical and R 3 representing hydrogen or an optionally substituted alkyl or aryl radical, or R 2 and R 3 forming a ring, optionally with inclusion of a hetero-atom, and X . . . halogen, such as chlorine or fluorine and their use for dyeing and printing materials containing hydroxyl groups or containing amide groups.

Substituted pentahydroxyhexylammonium salts, their fungicidal compositions and method of combating fungi.

Abstract: Fungicidal compositions containing a compound of the formula in which R , R and R are identical or different and represent an optionally alkoxycarbonyl-substituted alkyl radical, a cycloalkyl radical, an optionally substituted aralkyl radical and an optionally substituted aryl radical, and R and R moreover can be members of a joint 5- or 6-membered optionally heterocyclic ring, and X represents an acid radical, and corresponding pentahydroxyhexylammonium salts in which R , R and R are other than methyl.

New cyclopropanecarboxylic acid derivatives, process for their preparation and their application to the fight against parasites.

Abstract: The addition is intended to illustrate, by using new examples, the compounds of general formula (I) of the main patent, in which A denotes the residue of an alcohol radical, R denotes an alkyl radical substituted by one or more functional groups or a heterocyclic radical optionally substituted by one or more functional groups or an aryl radical optionally substituted by one or more functional groups. Another subject of the addition is individual processes for the preparation of some of the compounds of the addition. Another subject of the addition is the application of the compounds of the addition to the fight against parasites and the pesticidal compositions containing at least one of the compounds of the addition as active substance.

alpha -Alkoxy- alpha -trimethylsiloxycarboxylic acid esters, their preparation and use

Abstract: alpha -Alkoxy- alpha -trimethylsiloxycarboxylic acid esters of the general formula in which X denotes a radical of the formulae or R denotes an alkyl radical, R , R , R , R and R denote hydrogen atoms, alkyl radicals or aryl radicals and Ar denotes an aryl radical, a process for the preparation of these acid esters and their use for the preparation of alpha -ketocarboxylic acid esters.

Manufacture of surface treated ferromagnetic powder

Abstract: PURPOSE:To improve the dispersibility and abrasion resistance of ferromagnetic powder by a method wherein ferromagnetic powder is dispersed in an alkaline electrolytic solution and then dispersed again by a surface active agent of a specific composition. CONSTITUTION:Ferromagnetic powder is dispersed in an alkaline electrolytic solution and then dispersed again by a surface active agent whose composition is expressed by a general formula I or II. A hydrophobic organic solvent is added to that dispersed solution and the ferromagnetic powder is transferred to an organic layer and then taken out as the powder of required properties. In the formulae, R means a saturated or non-saturated alkyl radical with 1-30 carbon atoms or a substituted or non-sabstituted aryl radical with 6-30 carbon atoms, R and R mean a saturated or non-saturated and substituted or non-substituted alkyl radical with 1-20 carbon atoms or a hydrogen atom, R means a substituted or non-substituted alkyl radical with 1-10 carbon atoms, (n) means a positive integer 1-4, Q means a nitrogen atom or a carbon atom, Q-N means a saturated ring with 5 or 6 members, A means an organic or inorganic acid and (m) means a positive integer.

Olefin polymerisation catalyst

Abstract: Catalyst components for the stereoregular polymerization of alpha-olefins, comprising a Ti halide and an electron-donor compound supported on an anhydrous magnesium dihalide and obtained by means of non-extractive treatments, with liquids having a dielectric constant at 20 DEG C. equal to or higher than 2, of compositions comprising an anhydrous Mg dihalide, the crystallites of which have an average size lower than 300 ANGSTROM . The present invention refers to new catalyst components and the catalysts obtained therefrom for the polymerization of alpha-olefins Ch2=CHR, wherein R is an alkyl radical with 1-4 C atoms or an aryl radical, and of mixtures of said alpha-olefins with minor amounts of ethylene.

Optically active 3,4-methylenedioxyphenylbutane derivatives, process for their preparation, and their use

Abstract: The invention relates to novel optically active 3,4-methylenedioxyphenylbutane derivatives of the general formula I in which Z represents CH2-CH2 or CH = CH, and X represents amino, hydroxyl or esterified hydroxyl, the acyl radical of the ester group being R-CO or R-SO2, and where R denotes an optionally substituted alkyl or aryl radical, a plurality of processes for their preparation and their use as intermediates for the preparation of optically active pharmaceutical active compounds.