Showing papers on "Biflavonoid published in 1990"
TL;DR: Kolaviron, a mixture of Garcinia biflavonoids obtained from Garcinia kola, protected rats against the toxic effects of thioacetamide in vivo and reduced the thiopental‐induced sleep in thio acetamide‐poisoned rats, both in the chronic and acute test models.
Abstract: Kolaviron, a mixture of Garcinia biflavonoids GB-1 (II-3-I-4′-II-4″-I-5-II-5-I-7-II-7-heptahydroxy-3,8″-biflavanone), GB-2 (II-3-II-3′-I-4′-II-4″-I-5-II-5-I-7-II-7-octahydroxy-3,8″-biflavanone) and kolaflavanone (II-3-II-3′-II-4″-I-5-II-5-I-7-II-7-heptahydroxy-3,8″-biflavanone) obtained from Garcinia kola, protected rats against the toxic effects of thioacetamide in vivo. The biflavonoid mixture at a dose of 100mg/kg i.p. reduced the thiopental-induced sleep in thioacetamide-poisoned rats, both in the chronic and acute test models. The microsomal enzyme levels in the serum of rats poisoned with thioacetamide were also significantly altered by treatment with kolaviron.
42 citations
Journal Article•
23 citations
TL;DR: The hitherto unknown biflavone 5′-hydroxyrobustaflavone and the three known bIflavonoids 5-Hydroxyamentoflavone, 5′,3′′′-dihydroxyament oflav one and 2,3-Dihydro-5′- hydroxyaments oflavone have been isolated from Rhytidiadelphus squarrosus.
Abstract: From Rhytidiadelphus squarrosus the hitherto unknown biflavone 5′-hydroxyrobustaflavone and the three known biflavonoids 5′-hydroxyamentoflavone,5′,3′′′-dihydroxyamentoflavone and 2,3-dihydro-5′-hydroxyamentoflavone have been isolated.
8 citations