Showing papers on "Biflavonoid published in 1999"
TL;DR: Seven pure flavonoids were isolated and identified from five moss species and shown to have pronounced antibacterial effects against Enterobacter cloaceae, E. aerogenes and Pseudomonas aeruginosa.
303 citations
TL;DR: These biflavonoids all exhibited significant inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus early antigen activation in Raji cells.
Abstract: A new biflavonoid named pancibiflavonol (1) was isolated from an EtOH extract of the stem bark of Calophyllum panciflorum, along with six known biflavonoids, and its structure was elucidated by spectroscopic methods. These biflavonoids all exhibited significant inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus early antigen activation in Raji cells.
47 citations
TL;DR: In this article, the molecular orbital semi-empirical method AM1 is employed to calculate a set of molecular properties (variables) of 14 biflavonoid compounds with anti-HIV-1 activity.
Abstract: The molecular orbital semi-empirical method AM1 is employed to calculate a set of molecular properties (variables) of 14 biflavonoid compounds with anti-HIV-1 activity. Pattern recognition techniques, principal component analysis (PCA) and hierarchical cluster analysis (HCA), and stepwise discriminant analysis (SDA) were employed in order to reduce dimensionality and investigate which subset of variables should be more effective for classifying the biflavonoid compounds according to their degree of anti-HIV-1 activity. The PCA, HCA and SDA studies showed that the variables HOMO (the energy of the highest occupied molecular orbital), LUMO (the energy of the lowest unoccupied molecular orbital) and A (surface area) are responsible for the separation between compounds with higher and lower anti-HIV-1 activity.
29 citations