Showing papers on "Biflavonoid published in 2000"
TL;DR: An unusual biflavonoid named licoagrodin was isolated from the hairy root cultures of Glycyrrhiza glabra along with four known isoflavone glycosides, two flavone C-glycoside, and three other glycoside structures, which were elucidated on the basis of spectroscopic evidence.
136 citations
TL;DR: It was found that this compound exhibits potent and dose-related analgesic action in both experimental models, with ID50 ’s values of 4.2 and 6.8 μmol/kg against the first and second phase of the formalin test, respectively, several times more potent than some well-known analgesic drugs used as reference.
Abstract: This paper describes the isolation, identification and analgesic activity of a new biflavonoid from Rheedia gardneriana leaves, which correspond to I3-naringenin-II8-4'-OMe-eriodictyol (GB-2a-II-4'-OMe) (1), with a methoxyl group in position 4 of ring-II. Its structure was determined by spectroscopic data and confirmed by an alkaline hydrolysis. Its analgesic effect was evaluated in a writhing test and a formalin test in mice. It was found that this compound exhibits potent and dose-related analgesic action in both experimental models, with ID50's values of 4.5 micromol/kg against the writhing test and 8.2 and 6.8 micromol/kg against the first and second phase of the formalin test, respectively. It was several times more potent than some well-known analgesic drugs used as reference.
29 citations
Journal Article•
TL;DR: It is suggested that anti-inflammatory activity of the certain flavonoids (mainly flavones, flavonols and biflavonoids) may be mediated by direct inhibition of arachidonic acid metabolizing enzymes as well as suppression of the enzyme expression involved in inflammatory responses.
Abstract: Flavonoids are natural polyphenolic compounds widely distributed in plant kingdom. Although many flavonoids were found to show anti-inflammatory activity in vitro and in vivo, the potency of anti-inflammatory activity was not enough for a clinical trial. Thus, a search for finding potential flavonoid molecules is continuing. In this review, in vivo anti-inflammatory activity of various flavonoid derivatives is summarized mainly based on the results obtained in authors' laboratories. Among them, several biflavonoids such as amentoflavone and ginkgetin were found to possess anti-inflammatory activity on animal models of acute/chronic inflammation comparable to nonsteroidal and steroidal anti-inflammatory drugs currently used. In respect of their action mechanisms, the effects on arachidonic acid metabolism and nitric oxide production were described. Some flavonoids directly inhibit cyclooxygenase and/or lipoxygenase. Biflavones such as ochnaflavone and ginkgetin are inhibitors of phospholipase . In recent studies, certain flavonoids were also found to suppress cyclooxygenase-2 and inducible nitric oxide synthase expression induced by inflammatory stimuli. Therefore, it is suggested that anti-inflammatory activity of the certain flavonoids (mainly flavones, flavonols and biflavonoids) may be mediated by direct inhibition of arachidonic acid metabolizing enzymes as well as suppression of the enzyme expression involved in inflammatory responses.
12 citations
TL;DR: From Pilotrichella flexilis various flavonoids have been isolated, which contains in contrast to P. cuspidata not only 3′,3‴-binaringenin and related compounds, but also some hitherto unknown biflavonoids based on eriodictyol and aureusidin.
Abstract: From Pilotrichella flexilis various flavonoids have been isolated. This species contains in contrast to P. cuspidata not only 3',3'''-binaringenin and related compounds, but also some hitherto unknown biflavonoids based on eriodictyol and aureusidin. The structures of two new compounds are elucidated spectroscopically. Possible causes for the differences of the flavonoid patterns between the two species of the genus Pilotrichella are discussed.
6 citations