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Showing papers on "Chebulinic acid published in 2006"


Journal ArticleDOI
TL;DR: As a chromatographic column, the high-speed counter-current chromatography system was equipped with a preparative HPLC series, enabling the successful isolation of hydrolysable tannins from the fruits of Terminalia chebula, a traditional Chinese medicine.
Abstract: As a chromatographic column, the high-speed counter-current chromatography system was equipped with a preparative HPLC series, enabling the successful isolation of hydrolysable tannins from the fruits of Terminalia chebula, a traditional Chinese medicine. The two-phase solvent system was composed of n-hexane-ethyl acetate-methanol-water (1:20:1:20 v/v). As a result, 33.2 mg chebulagic and 15.8 mg chebulinic acids were obtained in one step from 300 mg of crude extract. Their purities were determined by HPLC to be 95.3 and 96.1%, respectively. The chemical structures were identified by their MS and 1H NMR spectra.

67 citations


Journal Article
TL;DR: In this paper, a scientific method for establishing the uses of Terminalia chebula based on composition of various chemical constituents has been presented, where a H.P.L.C method has been developed for simultaneous estimation of tannic acids, gallic acid, chebulinic acid and ethyl gallate.
Abstract: Terminalia chebula has been mentioned in traditional system of medicine for many diseases. This paper presents a scientific method for establishing its uses based on composition of various chemical constituents. H.P.L.C method has been developed for simultaneous estimation of tannic acid, gallic acid, chebulinic acid and ethyl gallate in different samples of Terminalia chebula. The results have shown a considerable change in these phyto nutrients in different samples of fruits of Terminalia chebula, which gives a new direction into scientific basis of its traditional uses.

32 citations


Journal ArticleDOI
TL;DR: Results suggested that restoring GJIC might be one explanation for tellimagrandin I antitumor effects, whereas chebulinic acid exerted antitumors action through other pathways.

24 citations