Showing papers on "Chromothripsis published in 1998"
TL;DR: The evidence for the role of the DNA double-strand break in directly induced and delayed chromosomal rearrangements is reviewed.
Abstract: DNA double-strand breaks can lead to chromosomal rearrangements at the first mitosis after exposure to the DNA strand-breaking agent. The evidence suggests a number of different pathways for DNA double-strand break rejoining in mammalian cells, but it is unclear what factors determine the fate of the induced break and whether or not it will lead to chromosomal rearrangement. If a cell does survive and proliferate after DNA cleavage, delayed chromosomal instability can be observed in the clonal descendants of the exposed cell. Most, but not all DNA double-strand breaking agents are effective at inducing this delayed chromosomal instability. In this paper, we review the evidence for the role of the DNA double-strand break in directly induced and delayed chromosomal rearrangements.
112 citations
TL;DR: The frequency of all kinds of breaks per cell in RV-stained chromosomes (chromosomal/chromatid breaks and breaks in structural aberrations) was comparable to the rate in Gbanded chromosomes, i.e. 0.03 and 0.02, respectively.
Abstract: We identified a higher percentage of chromosomal and chromatid breaks in RV-stained chromosomes (2.78%) than in the G-banded chromosomes (1.62%). The G-banding technique was more useful for revealing chromosomal rearrangements (0.24%) than RV method (0.11%). The frequency of all kinds of breaks per cell in RV-stained chromosomes (chromosomal/chromatid breaks and breaks in structural aberrations) was comparable to the rate in Gbanded chromosomes, i.e. 0.03 and 0.02, respectively. We continued our studies on chromosomal abnormalities in cancer patients by using G-banded chromosomes only, because in this way we could get more detailed information
4 citations