Showing papers on "Clear-cell sarcoma published in 1996"
TL;DR: A sensitive immunohistochemical technique was established to localize the WT1 gene product in archival normal tissues and paediatric renal tumour samples, providing an insight into the interrelationships of these renal tumours.
Abstract: WT1, the Wilms' tumour suppressor gene located at chromosome 11p13, plays an important role in the development of the kidney. It is mutated in 10 per cent of Wilms' tumours (WTs) and their putative precursors called nephrogenic rests (NRs). A sensitive immunohistochemical technique was established to localize the WT1 gene product in archival normal tissues and paediatric renal tumour samples. Strong nuclear signal was seen in the various sites such as the kidneys, gonads, and decidua. Nuclear immunoreactivity of variable intensity was also seen in the skeletal muscle, smooth muscle of urinary bladder, ureter, and arteries. All 28 WTs (including the anaplastic variant) showed the WT1 gene product in a varying proportion of the blastema, epithelium, and stroma. The anaplastic nuclei in six WTs showed an intensity of staining comparable to their adjacent favourable histology counterparts. All the intralobar and perilobar types of NR demonstrated the WT1 gene product. All three malignant rhabdoid tumours were positive, while three of four mesoblastic nephromas and a clear cell sarcoma were negative. These findings provide an insight into the interrelationships of these renal tumours.
73 citations
TL;DR: To the authors' knowledge, there has been no previous report of primary malignant melanoma of bone in humans, and this is the first report of its kind in the literature.
Abstract: BACKGROUND. To the authors' knowledge, there has been no previous report of primary malignant melanoma of bone. METHODS. A 33-year-old woman presented with a tumorous lesion in the olecranon of the right ulna. The histologic diagnosis was malignant melanoma with close similarity to clear cell sarcoma. To exclude the possibility of malignant melanoma metastatic to the bone, clinical investigations including gallium 67-citrate scintigraphy, brain, chest, and abdominal computed tomography, and upper and lower gastrointestinal endoscopic examinations were performed. Conventional histopathologic, immunohistochemical, and electron microscopic studies were also performed. RESULTS. Clinical investigations showed no lesion suggestive of a primary melanoma other than that in the right ulna. Histologically, the tumor was comprised of polygonal or fusiform cells with clear or granular cytoplasm and vesicular nuclei containing one or two prominent nucleoli. The features were similar to those of clear cell sarcoma (malignant melanoma of soft parts). Fontana preparations and immunohistochemical staining for S-100 protein and HMB-45 (melanoma specific antigen) also revealed that the tumor cells had the characteristics of malignant melanoma. The patient has remained alive and well for more than 5 years after the initial treatment. CONCLUSIONS. The clinicopathologic findings in this case strongly suggested that the lesion was a primary malignant melanoma of bone. Therefore, this is the first report to indicate that malignant melanoma and related diseases can occur even in bone tissue.
29 citations
TL;DR: The establishment and characterisation of paired autologous tumour cell line (MST-1) and tumour-infiltrating lymphocyte (TIL) culture from a tumour mass of a 14-year-old Taiwanese girl with soft tissue melanoma are described to provide useful materials for identifying T-cell-defined antigens as a model system for devising individualised cancer biotherapeutic strategies.
19 citations
TL;DR: This case illustrates the usefulness of cytogenetic analysis in the differential diagnosis of CCS and malignant melanoma, and extra copies of chromosomes 8, 7, and 2 seem to play an important, although at present not understood, role in the development of C CS.
19 citations
TL;DR: A 21-year-old man presented with a painless lump on the ulnar side of the volar aspect of his left forearm near the elbow, which had been increasing in size over the previous 3 months.
Abstract: A 21-year-old man presented with a painless lump on the ulnar side of the volar aspect of his left forearm near the elbow. The mass had been increasing in size over the previous 3 months. Physical examination revealed a non-tender, uniformly firm mass measuring 3–4 cm in diameter. Radiographs were not obtained and the patient was referred directly for magnetic resonance imaging (MRI). MRI showed a mass measuring 4×3×2.5 cm between the pronator teres and brachialis muscles in the expected location of the median nerve. The mass was smoothly marginated and elliptical, with its long axis aligned with that of the forearm. It was slightly heterogeneous on T1weighted images, with a signal intensity between those of fat and muscle (Fig. 1). Short-tau inversion recovery (STIR) images showed uniformly high signal intensity within the mass (Fig. 2). Intravenous gadolinium (Gd)-DTPA enhanced the lesion only minimally (Figs. 3, 4). The mass was surgically excised. A diag197
16 citations
TL;DR: It is reasonably suggestive that alterations in the p53 tumor suppressor gene do occur in CCSK, and the relative prevalence and importance of p53 mutational events in the pathogenesis of this aggressive renal tumor of childhood.
14 citations
TL;DR: A 19-year-old woman presented with hematuria and flank pain and right nephrectomy was performed, and histopathological examination revealed clear cell sarcoma of the kidney, which was confirmed by reexamination of the pathology slides.
7 citations
TL;DR: Clear cell sarcoma of tendons and aponeuroses is a rare tumor with a predilection for the lower extremities, particularly the foot, which has a poor prognostic outlook and is sometimes characterized by a slow clinical course.
Abstract: Clear cell sarcoma of tendons and aponeuroses is a rare tumor with a predilection for the lower extremities, particularly the foot. Although it is claimed to have a poor prognostic outlook, it is sometimes characterized by a slow clinical course. The authors report a case with a prolonged survival period of 7 years—5 years in the presence of multiple lung metastases.
3 citations
Journal Article•
TL;DR: Gonadal neoplasms with emphasis on germ cell tumors of these organs are presented and the multidisciplinary approach and importance of the pediatric surgical oncologist in the management of genitourinary tumors in childhood are emphasized.
3 citations
20 May 1996
TL;DR: The histological diagnosis was epithelioid malignant schwannoma with rhabdoid features in a 23-year-old female that had a 5 months history of agressively enlarging subcutaneous nodule of the scalp with histologic features of malignant rhabDoid tumor (MRT).
Abstract: We present here a subcutaneous tumor in a 23-year-old female that had a 5 months history of agressively enlarging subcutaneous nodule of the scalp with histologic features of malignant rhabdoid tumor (MRT) . Histologically, the tumor consisted of varying cellularity, and mainly composed of cords of cells with deeply eosinophilic cytoplasm, clear cells reminiscent of clear cell sarcoma, solidly sheets somewhat reminiscent of primitive neuroectodermal tumor, discohesive eosinophilic cells of having features of the MRT and the aggregation of spindle cells containing peripheral nerve-like organoid structures in a small area. Immunohistochemistry revealed the presence of neuron specific enolase, S-100 protein and vimenin within the tumor cells. A few spindel or dendritic cells were stained positively for anti-keratin. The p53 supressor gene protein was also positive, especially in the rhabdoid cells. We speculat-ed the tumor cells in this case revealed the neuroectodermal associated differentiaion, mainly differentiated towards the schwann cell. We concluded that the histological diagnosis was epithelioid malignant schwannoma with rhabdoid features. She was alive and well 7 months with no evidence of disease.
01 Jan 1996
TL;DR: The majority of abdominal masses in children are benign and a large number of them are cystic, where the cystic mass originates from the urinary tract and is due to some obstructive lesion.
Abstract: The majority of abdominal masses in children are benign and a large number of them are cystic. A cystic mass is almost always benign, especially in the young child. In a vast majority, the cystic mass originates from the urinary tract and is due to some obstructive lesion, especially in a newborn or infant. Solid or heterogenic malignant abdominal masses are often characteristic of the child’s age. The origin of an abdominal mass may be a malformation, a neoplasia, trauma (including an iatrogenic lesion) or an inflammatory or metabolic process.