Showing papers on "Cytopenia published in 1975"
TL;DR: The operation was associated with acceptable mortality and morbidity despite the advanced stage of disease in most cases and increased splenic activity should be considered as a cause of a haematological cytopenia in patients with malignant lymphomas even in those with bone-marrow involvement.
29 citations
TL;DR: Three essential features characterize the syndrome of hypersplenism: splenomegaly, cytopenia(s) associated with hyperplasia of bone marrow, and correction of the cy topenia by splenectomy.
7 citations
TL;DR: Conventional therapy proved of little value in the poorly differentiated group, and trials of intensive multidrug chemotherapeutic regimens seem warranted, despite the risk of exacerbating the cytopenia.
Abstract: In reviewing 550 patients with non-Hodgkin's lymphoma, only 3 percent were found to present with severe leukopenia or thrombocytopenia due to bone marrow infiltration. Patients with well-differentiated lymphoma had a favorable prognosis despite the presence of cytopenia. In contrast, individuals with poorly differentiated lymphoma had a median survival of only 4 months. Thus, the critical factor in survival was the degree of differentiation of the lymphoma. Conventional therapy proved of little value in the poorly differentiated group. Trials of intensive multidrug chemotherapeutic regimens seem warranted, despite the risk of exacerbating the cytopenia.
4 citations