Showing papers on "Dibutyl phthalate published in 1980"

Toxicological Studies on Phthalate Esters

Abstract: A quick, simple and accurate method for the quantitative analysis of phthalate esters and their metabolites in rat urine was devised. The chemicals in urine extracted into ethyl acetate were injected into a gaschromatograph-mass spectrograph system and their mass phragmentgraphy was taken at 149m/e.When administered into the stomach, most diethyl phthalate (DEP) and dibutyl phthalate (DBP) metabolized to monoester and phthalic acid and were rapidly excreted into the urine.Rats exposed to DBP aerosols at concentrations of 50mg/m3, 6 hours daily for 6 months, showed some DBP accumulations in internal organs, of which the levels in the brain and lungs were most remarkable.In some cases DBP concentrations in the brain was several times greater than in other organs. Brain accumulations were comparatively slight, in rats exposed only to 0.5mg/m3 DBP.The results suggest that the adverse effects of phthalate esters arise from their accumulations in the brain and from their metabolite toxicities.

Multifunctionality of douglas-fir beetle pheromone 3,2-mch confirmed with solvent dibutyl phthalate

Abstract: Previous field and laboratory tests withDendroctonus pseudotsugae showing increased attractancy and chirp evocation by very low concentrations of the pheromone 3-methylcyclohex-2-en-1-one (3,2-MCH) dissolved in ethanol with known attractants were repeated with a different diluent, dibutyl phthalate (DBP). Other workers had speculated that the solvent ethanol was actually the synergist. Beetle response was essentially identical with both solvents, confirming the concentration-dependent multifunctionality of 3,2-MCH in Douglas-fir beetle behavior. Contradictions in available data with ethanol indicate unanswered questions about its effect withDendroctonus attractants.

Vinyl chloride resin composition

Abstract: PURPOSE:To prepare the title composition for rubber elastomer having low compression set, by compounding a vinyl chloride resin containing a specific amount of gel component, with a plasticizer and a reactive plasticizer CONSTITUTION:A resin composition having a compression set of <=45%, is prepared by blending (A) 100 parts by weight of a vinyl chloride resin composed of 35-70wt% of a gel component insoluble to tetrahydrofuran, and the remaining part of a component soluble to tetrahydrofuran and having an average polymerization degree of 800-10000, pref 900-7000, (B) 5-160 parts of a plasticizer (eg dibutyl phthalate), (C) 5-70wt%, based on the (B) component, of a reactive plasticizer (eg diallyl phthalate), and if necessary, (D) other thermoplastic resins, organic peroxides, heat stabilizers, fillers, pigments, lubricants, etc

Flexible polyvinyl chloride resin composition

Abstract: PURPOSE: Dialkyl phthalate, chlorinated paraffin, clay and a benzotriazole are added to a vinyl chloride resin to produce the titled composition with remarkably improved flame retardancy and insulation. CONSTITUTION: To 100pts.wt. of the resin are added 30W80pts of a dialkyl phthalate, preferably dibutyl phthalate, 5W30pts. of a chlorinated paraffin, preferably a chlorination product from 10W40C n-parafin with 10W80wt% chlorine content, 5W20pts of a clay, preferably composed of hydrated aluminum silicate as a major component, and 0.001W0.1pt. of a benzotriazole, preferably 1,2,3-benzotriazole. Further, a metal salt of inorganic acid, organic acid or phenol also is used as a stabilizer. COPYRIGHT: (C)1981,JPO&Japio

Accumulation of triacylglycerol in tissue culture cells derived from human embryonic lung (L-132 cells) on administration of di-n-butyl phthalate.

Abstract: Effect of di-n-butyl phthalate on the cultured epithelium-like cells derived from human embryo lung (L-132 cells) was investigated. Suppression of cell growth, morphological change to jagged shapes of the cells, and the appearance of many lipid droplets in the cytoplasm of the cells occurred by the addition of dibutyl phthalate in the culture medium (40 micrograms/ml). Remarkable amount of triacylglycerol accumulated (7-10 fold) in the cytosol of the cells cultured in the medium containing dibutyl phthalate (40 micrograms/ml). The level of cholesterol and protein did not change and phospholipid decreased a little in its content. It was confirmed that short term-labeling of cellular triacylglycerol with [U-14C]glucose or [1-14C]oleic acid was remarkably stimulated in the phthalate ester-treated cells, and the incorporation of the radioactivity into phospholipid fraction decreased simultaneously. Decrease in the disappearance rate of the radioactivity of short term-labeled triacyglycerol was also observed. The above results indicate a possibility that the accumulation of triacylglycerol by the phthalate ester was due to the stimulation of its synthesis mainly through de novo pathway with the concomitant depression of its degradation. The accumulation of the cellular triacylglycerol was reversibly dissolved by the removal of dibutyl phthalate from the culture medium.