Showing papers on "Fibrinoid necrosis published in 1972"

Granulomatous prostatitis with emphasis on the eosinophilic variety.

Abstract: Twenty-eight cases of nonspecific granulomatous prostatitis are presented. Those cases showing an eosinophilic infiltrate are reported in detail and analyzed with ones found in a comprehensive review of the literature. Simple eosinophilic granulomatous prostatis is occasionally associated with an allergic history (20%); those cases containing the additional element of fibrinoid necrosis or vasculitis almost invariably have an allergic history (94%). Eosinophilic granulomatous prostatitis does not indicate a grave prognosis unless associated with diffuse vasculitis. A history of previous prostatic transurethral resection was present in 47% of our patients with nonspecific granulomatous prostatitis, all of whom had benign prostatic hypertrophy. The significance of this finding together with other factors in the pathogenesis of prostatic granulomas is discussed. The bladder was involved in two cases of eosinophilic granulomatous prostatis in our series. This association, so far as we are aware, has not been reported previously. A histologic classification of nonspecific granulomatous prostatitis is suggested.

Pathology of Systemic Lupus Erythematosus

Abstract: Histological and histochemcal studies of systemic lupus erythematosus (SLE) were performed on 31 autopsy cases. Results obtained and brief comments on them were as follows. Hematoxylin bodies (HX bodies) and fibrinoid necrosis of the vascular system were the main pathologic condions in SLE. HX bodies were found in 16 cases, with regularity in areas of fibrinoid necrosis. They were considered to represent the in vivo counterpart of the in vitro LE phenomenon, even though some tinctorial characteristics were different. HX bodies were PAS positive, not metachromatic, and might show reduced Feulgen reaction. When some of HX bodies were ingested by polymorphonuclear luekocytes, LE cells could be detected in the tissue. Fibrinoid necrosis had occasionally been described in other conditions and considered not pathognomonic of SLE. However, in SLE vascular lesions were widespread, and so often took the form of fibrinoid necrosis. Not only Libman-Sacks endocarditis but also glomerular lesions called “wire loop” lesion and “hyaline thrombi” could be regarded as variants of fibrinoid necrosis. In this meaning, fibrinoid necrosis could be regarded as almost pathognomonic of SLE. Fibrinoid necrosis of small vessels was frequent and encountered in 16 cases. Severe necrotizing angiitis as seen in periarteritis nodosa was noted in 6 cases. Endocarditis occurred in 10 cases and fully developed lesions conforming to the description of Libman and Sacks were present in 5 cases. Fibrinoid necrosis of the cardiovascular system was a common site of HX bodies, and not infrequently had a diffuse hematoxyphilic tincture suggesting the deposition of the nuclear substance. Lupus nephritis characterized by pleomorphic and irregular glomerular damage was noted in 25 cases. The most distinctive features included necrosis (often fibrinoid necrosis), karyorrhexis, hyaline thrombi, wire loop lesion and HX bodies. The frequency of the latter three findings was 48%, 61% and 39%, respctively. Thickening of the basement membrane refered to as wire loop lesion was brightly eosinophilic and a hard refractile appearance. Hyaline thrombi were eosinophilic globules filling the lumen of capillaries and closely resembled wire loop lesions. Both lesions had similar staining properties as noted in the vascular fibrinoid and were frequent sites of HX bodies. They showed not rarely a rather diffuse hematoxyphilic tincture, where Feulgen reaction was weakly positive. Another important and the most frequent change in SLE was the concentric lamination of dense collagen fibers arround the central arterioles of the spleen. This change called onion skin lesion was noted in 29 cases. The most remarkable pulmonary change in SLE was a variety of the interstitial pneumonia. This lesion occurred in 11 cases and the most distinctive features included were alveolar exsudate containing fibrin, hyaline membrane, HX bodies, formation of Masson bodies, and fibrosis of alveolar septa. The majority of lesions in SLE might be induced by the immune complexes deposited in the affected vessels. The lesion is histologically characterized by changes in the vessel wall leading to fibrinoid necrosis and the basement membrane thickening, in which deposition of immunoglobulin, complement and fibrinogen are detected. The presence of hematoxyphilic substance with positive Feulgen reaction suggests the deposition of the nuclear substance. Actually DNA antigen has been demonstrated in the glomeruli and the acid eluate from affected glomeruli is said to be rich in antinuclear antibodies. When regard to the pathogeneis of SLE, simultaneous presence of DNA and anti-DNA antibodies in the lesion should raise attention to the role of immune complexes on the vascular system including renal glomeruli.