Showing papers on "Generalized anxiety disorder published in 1982"

Panic and Generalized Anxiety Disorders: Developmental Antecedents and Precipitants

Abstract: • Seventeen subjects with panic disorder (PD) and 16 subjects with generalized anxiety disorder (GAD) were interviewed to obtain their developmental and psychiatric histories. The groups reported a similar incidence of early separation, separation disorder in childhood, and separation causing exacerbation of symptoms. The groups differed significantly in that those with PD had a higher incidence of a grossly disturbed childhood environment and major depressive episodes. The results of this preliminary study support the validity of the DSM-III distinction between PD and GAD.

A double-blind comparison of buspirone and diazepam in outpatients with generalized anxiety disorder.

Abstract: The safety and antianxiety and antidepressive effects of buspirone (average 16.5 mg/day) were compared in a double-blind trial with those of diazepam (15 mg/day). The two drugs were nearly equivalent in relieving symptoms of both anxiety and depression in 100 patients. Scores on the impaired cognition factor of the SCL-56 and confusion factor of the POMS showed significantly greater improvement with buspirone than with diazepam. Side effects, such as sedation and drowsiness, were significantly more frequent and severe with diazepam. Buspirone may be particularly indicated for anxious patients with associated depression.

Pharmacologic treatment of anxiety disorders.

Abstract: The benzodiazepines and the beta-adrenergic blockers are effective in the treatment of anxiety neurosis (generalized anxiety disorder and panic disorder) but offer little help in the treatment of agoraphobia and obsessive-compulsive disorders. The antidepressants are often effective in agoraphobia and obsessive-compulsive disorders, and the evidence suggests that their antipanic and antiobsessional effects may be independent of their antidepressant properties. There is suggestive evidence linking the antiobsessional effect to a specific neurotransmitter (serotonin) system.

A therapeutic and discontinuation study of clobazam and diazepam in anxiety neurosis.

Abstract: The efficacy and safety of clobazam and diazepam were compared in 40 patients with generalized anxiety disorder in a 28 day non-placebo-controlled trial followed by a 3-day single-blind placebo washout. The two drugs were equally anxiolytic, and the anxiety symptoms of most patients were brought under control within 1 week. Both drugs were found to be nontoxic. Diazepam had slightly greater sedative properties than clobazam, which was the patients' preferred drug after 28 days of treatment. During placebo washout, anxiety returned to pretreatment levels. Abrupt withdrawal did not result in rebound phenomena.