Showing papers on "Growth factor receptor inhibitor published in 1974"
TL;DR: Epidermal growth factor, a 6,400-dalton polypeptide from the mouse submaxillary gland, binds specifically to cells and membranes derived from a variety of human, rat, mouse, and bovine tissues.
224 citations
TL;DR: An overview of the growth hormone and somatomedin is provided, which shows how growth hormone promotes protein synthesis by stimulating the appearance in the tissues of a secondary factor, sulfation factor, which transfers the action of the hormone to the tissues.
Abstract: Publisher Summary This chapter provides an overview of the growth hormone and somatomedin. It is well established that growth hormone in vivo promotes skeletal growth and protein synthesis. Growth hormone promotes protein synthesis by stimulating the appearance in the tissues of a secondary factor, sulfation factor or somatomedin, which transfers the action of the hormone to the tissues. Other apparently tissue-specific growth factors such as the nerve growth factor and the epidermal growth factor seem to stimulate protein synthesis and act in insulin like manner in their respective target tissues. Somatomedin induced by growth hormone in a variety of growth hormone-sensitive tissues is identical with somatomedin in human plasma. The in vivo , growth hormone not only stimulates protein synthesis but also increases the mobilization of fat and increases the extracellular glucose pool. This action of growth hormone might be a direct one on the tissue but it cannot be excluded that it is mediated by some other factor produced in the tissues.
31 citations