Showing papers on "Hypersensitivity reaction published in 1972"
TL;DR: Anaphylactic shock is the classic example of the immediate type of hypersensitivity reaction; it may be defined as the failure of the peripheral circulation induced by an antigen-antibody reaction.
Abstract: The concept of anaphylaxis originates from the observations by the French physiologist Charles Richet in 1902 of the effects of actinotoxins on the blood pressure of dogs [1]. Anaphylactic shock is the classic example of the immediate type of hypersensitivity reaction; it may be defined as the failure of the peripheral circulation induced by an antigen-antibody reaction [2]. The circulatory collapse may be primary, if the circulatory reaction is the primary event, or secondary, if the circulatory collapse is the consequence of an initial respiratory insufficiency.
135 citations
TL;DR: V vibratory angioedema is a hereditary, immediate-type, nonimmunologic physical hypersensitivity reaction that may be associated with vasoactive mediator release that is inherited as a Mendelian-dominant characteristic.
Abstract: A new clinical entity has been termed vibratory angioedema (VA). This is inherited as a Mendelian-dominant characteristic. The manifestations consist of local erythematous and edematotis lesions following local stimuli of a vibratory or fractional nature. Marked local reactions are accompanied by facial or generalised erythema and headache. The systemic manifestations subsequent to intense local stimulation suggested the release of a vasoactive amine. Further evidence for this was provided by detection of elevated plasma amine levels in venous blood from an extremity following an appropriate stimulus. It was not established that this material was histamine or that it was an active participant in the local or systemic reaction. VA is a hereditary, immediate-type, nonimmunologic physical hypersensitivity reaction that may be associated with vasoactive mediator release.
71 citations
TL;DR: The phenolic compounds do not appear to be responsible for the necrotic hypersensitivity and their production is one of the secondary effects of the virus infection.
60 citations
TL;DR: Respiratory disease resulting from prolonged exposure to logs contaminated with Alternariamay could be owing to a hypersensitivity reaction.
Abstract: Respiratory disease resulting from prolonged exposure to logs contaminated withAlternariamay be owing to a hypersensitivity reaction. Two patients had heavy and prolonged exposure to this ...
56 citations
TL;DR: Specific histopathologic patterns develop in guinea pig lungs depending on the type of participating hypersensitivity reaction, which should help clarify the pathogenesis of human diseases of suspected immunologic origin involving the lung as the target organ.
46 citations
Journal Article•
TL;DR: A new in vitro model for study of immediate (type I) cutaneous hypersensitivity in man is described, in which antigen-induced histamine release from thin slices of human skin which have been passively sensitized by human reaginic serum is measured.
Abstract: A new in vitro model for study of immediate (type I) cutaneous hypersensitivity in man is described, in which antigen-induced histamine release from thin slices of human skin which have been passively sensitized by human reaginic serum is measured. Evidence is presented confirming that the observed histamine release is due to a reaction between antigen and IgE antibody. In further experiments the effect of temperature, antiserum concentration and duration of passive sensitization on the magnitude of antigen-induced histamine release is studied. Studies of the relationship of temperature of incubation of sensitized skin with antigen raise the possibility that the mechanism of IgE-mediated hypersensitivity reaction in skin and in other tissues may differ.
28 citations
TL;DR: A patient who was receiving aurothioglucose developed a severe reaction characterized by dermatitis, alopecia, and fever that suggested that the reaction was allergic in origin.
Abstract: A patient who was receiving aurothioglucose developed a severe reaction characterized by dermatitis, alopecia, and fever. A positive lymphocyte transformation test with aurothioglucose as the test antigen in addition to other clinical and laboratory findings suggested that the reaction was allergic in origin.
18 citations
Journal Article•
TL;DR: From the results of chemical and physical analysis done on the purified carbohydrates obtained from these microorganisms, it was shown that these materials were devoid of demonstrable protein, RNA and DNA materials.
Abstract: The ability of purified polysaccharides, isolated from either Nocardia asteroides or Nocardia brasiliensis , to elicit a delayed-type hypersensitivity reaction was studied. From the results of chemical and physical analysis done on the purified carbohydrates obtained from these microorganisms, it was shown that these materials were devoid of demonstrable protein, RNA and DNA materials. Both polysaccharides, separately, elicited a delayed-type hypersensitivity reaction when they were skin tested in either N. asteroides - or N. brasiliensis -sensitized guinea pigs. The skin reaction, however, was usually larger in homologous sensitized animals. In addition, they also elicited an Arthus-type reaction. The presence of a common polysaccharide among them was shown by passive cutaneous anaphylatic (PCA) and double diffusion assays. Meanwhile, the carbohydrates did not induce any inflammatory reaction in nonsensitized animals.
12 citations
TL;DR: It is brought to the attention that one of the preservatives in dexamethasone (Decadron) is methylparaben, which raises the question of choice of steroid preparation that should be used for the treatment of hypersensitivity reactions.
Abstract: To the Editor.— The recent article entitled "Sudden Appearance of Cardiac Arrhythmias" by Schmidt et al 1 brought to our attention that one of the preservatives in dexamethasone (Decadron) is methylparaben. Methyl and propyl parabens are used extensively as preservatives in local anesthetics and parenteral penicillin preparations. These drugs can cause hypersensitivity reactions. Paraben allergies have already been cited as a cause of intractable dermatitis by Schorr. 2 A possible cross-sensitivity between the parabens, which are derivatives of parahydroxybenzoic acid, and structurally related procaine has been postulated by deJong. 3 This raises the question of choice of steroid preparation that should be used for the treatment of hypersensitivity reactions. Many injectable preparations of steroids contain parabens and it would seem advisable to select one that does not. If a hypersensitivity reaction is due to a preservative, then addition of more of this preservative with a steroid would be inappropriate. Perhaps
2 citations