Showing papers on "Hypersensitivity reaction published in 1973"

Hypersensitivity to phenylglycine acid chloride

Abstract: Twenty-four industrial workers, some of whom had respiratory symptoms on exposure to phenylglycine add chloride (PG-AC), were evaluated. A univalent and several polyvalent conjugates of PG-AC were synthesized for skin testing. Based on history, skin testing, Prausnitz-Kustner (P-K) studies, and inhalation challenge, evidence is presented that in some instances the respiratory symptoms elicited by PG-AC are immunologically mediated, apparently via a Type I immediate hypersensitivity reaction involving reaginic antibody.

Isoniazid Administration and Liver Injury

Abstract: Isoniazid has been recognized as a cause of liver dysfunction in some patients receiving antituberculous therapy. The medical literature contains reports of isoniazid-induced hepatic injury in adults, but essentially none in children. We used this drug to treat a 6-year-old Caucasian boy for active tuberculosis, and he suffered a reaction characterized by high fever, a morbilliform exanthem, peripheral eosinophilia, enlargement of the liver, and abnormal liver function and histologic findings. The histologic appearance of the liver lesion and the clinical manifestations were suggestive of a hypersensitivity reaction, probably of the delayed type.