Showing papers on "Invasive lobular carcinoma published in 1989"
TL;DR: Nuclear grade would appear to identify subsets of DCIS more likely to produce local failure after tylectomy alone, with duct carcinoma in situ with high‐grade nuclear morphology and comedo‐type necrosis associated with a 19% local recurrence rate after an average interval of 26 months.
Abstract: Seventy-nine patients with mammographically detected foci of duct carcinoma in situ (DCIS) of histologically confirmed extents of 25 mm or less, were treated by tylectomy without irradiation or axillary dissection. Adequacy of excision was confirmed histologically, by radiographic-pathologic correlation and by postoperative mammographic examination. Eight patients (10.1%) have recurred locally in the immediate vicinity of the biopsy site. Four patients developed recurrent in situ disease identified mammographically, and all were initially treated by reexcision. One of these patients subsequently elected to undergo mastectomy; no residual in situ or invasive disease was detected in the breast or in axillary lymph nodes. Four patients developed recurrent invasive disease; 50% of these recurrences were detected mammographically. All patients were treated by mastectomy with node dissection. Three had confirmed minimal invasive carcinomas and were N0, one patient had a 13-mm invasive lobular carcinoma with a single Group I micrometastasis. All patients, including those treated for a recurrence, are presently free of disease but three patients died of heart disease. Nuclear grade would appear to identify subsets of DCIS more likely to produce local failure after tylectomy alone. Duct carcinoma in situ with high-grade nuclear morphology and comedo-type necrosis was associated with a 19% local recurrence rate after an average interval of 26 months; only one of ten patients with intermediate-grade DCIS developed a local recurrence at 87 months; and none of 33 patients with DCIS of micropapillary/nonnecrotic cribriform type and low-grade nuclear morphology developed local recurrence in the follow-up period.
549 citations
TL;DR: One hundred and seventy-one cases of operable invasive lobular carcinoma, presenting over an 11-year period, were reviewed and the tubulo-lobular subtype was found to be more likely to be of good histological grade and node negative.
Abstract: One hundred and seventy-one cases of operable invasive lobular carcinoma, presenting over an 11-year period, were reviewed. Histological subtypes were investigated to determine differences in their clinical behaviour and whether these differences could be explained by histopathological features. Five subtypes were identified: mixed (45.6%), classical (30.4%), tubulo-lobular (13.5%), solid (6.4%) and alveolar (4.1%). The median follow-up period was 64 months and the median age 54 years. The 12-year actuarial survival rate was 100% for the tubulo-lobular subtype, but only 47% for the solid variant. Similar differences were found in the disease free interval, locoregional and distant metastatic rates between these two subtypes. The tubulo-lobular tumours were more likely to be of good histological grade and node negative. The other three subtypes did not differ significantly in their histopathological parameters, reflected in similar clinical behaviour. They occupied an intermediate position between the other two subtypes in terms of prognosis.
95 citations
TL;DR: Only one patient was found to have a malignancy, who had cytologically benign and mammographically 'probably benign' disease: this was an invasive lobular carcinoma with a dominant in-situ component and may well have been an incidental finding on biopsy.
29 citations
TL;DR: It is postulated that the characteristic infiltration pattern of lobular carcinoma may be attributed in part to paucity of stromal fibronectin.
Abstract: Fifty-four cases of invasive carcinoma of breast were immunostained for fibronectin and laminin. They included 36 cases of invasive ductal carcinoma and 18 cases of invasive lobular carcinoma. Although there was some heterogeneity within tumours, it was found that whilst the majority of ductal carcinomas (31/36) had abundant fibronectin at cell/stroma boundaries or diffusely throughout stroma, a substantial proportion of lobular carcinomas (12/18) had very little (P less than 0.001). This difference could not be related to differences in laminin immunoreactivity, which was most commonly scanty or absent in both tumour types. It is postulated that the characteristic infiltration pattern of lobular carcinoma may be attributed in part to paucity of stromal fibronectin.
24 citations
01 Jan 1989
TL;DR: The tumor cells in both in situ and invasive carcinoma may be arranged in a variety of ways or exhibit specific features, and these are used in providing the basis for the histological classification of breast carcinoma.
Abstract: Carcinoma is a malignant tumor derived from epithelial cells. In the breast, epithelial cell line ducts, and acini or lobules. In these sites malignant transformation is indicated microscopically by the presence of morphological changes within the individual cells and by the way in which these cells are arranged in relationship to each other. As long as the proliferating malignant cells are present within the confinement of the basement membrane surrounding the ducts, acini, or the covering surface epithelium of the nipple, the tumor is considered an in situ carcinoma. When the basement membrane is breached and the malignant cells are seen infiltrating the breast stroma and tissue spaces, the tumor becomes an invasive carcinoma. The tumor cells in both in situ and invasive carcinoma may be arranged in a variety of ways or exhibit specific features, and these are used in providing the basis for the histological classification of breast carcinoma.
2 citations