Showing papers on "Koenigs–Knorr reaction published in 2009"
TL;DR: Glycosylation of alcohols containing acid-sensitive groups, such as 1,2-5,6-di-O-isopropylidene-glucofuranose, Fmoc-threonine tert-butyl ester or famesol, is achieved using glycosyl trichloroacetimidates activated by gold(I) chloride (5―10 mol%).
Abstract: Glycosylation of alcohols containing acid-sensitive groups, as tor example 1,2-5,6-di-O-isopropylidene-glucofuranose, Fmoc-threonine tert-butyl ester or famesol, is achieved using glycosyl trichloroacetimidates activated by gold(I) chloride (5―10 mol%). While glycosylation with 2-O-acyl protected glycosyl donors proceeds with 1,2-trans-selectivity, non-neighboring group active glycosyldonors give mixtures of anomeric glycosides or α-glycosides depending upon their structure and the reactivity of the glycosyl acceptor.
10 citations