Showing papers on "Large cell published in 1974"
TL;DR: Adriamycin at doses below the cumulative cardiotoxic threshold appears to be of clinical value in advanced bronchogenic carcinoma.
Abstract: Adriamycin, a new cytotoxic antibiotic with antitumor activity in a variety of neoplasms, was given to 31 patients with advanced bronchogenic carcinoma. The doses used were 30 and 35 mg/m2 of body surface area daily for 3 days repeated at 3- or 4-week intervals. Objective regression (<50%) was seen in 4 of 20 patients receiving 30 mg/m2 and 5 of 11 patients receiving 35 mg/m2. Regressions according to histologic cell type were seen in 5 of 17 adenocarcinomas, 3 of 6 small cell carcinomas, 1 of 6 large cell anaplastic carcinomas, and 0 of 2 squamous cell carcinomas. Those patients who attained tumor regression survived longer than those who had progression. Toxic manifestations of Adriamycin administration were myelosuppression, stomatitis, cardiomyopathy, and nausea and vomiting. Adriamycin at doses below the cumulative cardiotoxic threshold appears to be of clinical value in advanced bronchogenic carcinoma.
33 citations
TL;DR: It was concluded that in assessing the role of histopathology in the prognosis of lung cancer, the mutual relationship to other pathological factors must be taken into account.
Abstract: The post-operative survival in 554 lung carcinomata, classified according to the histological type, was calculated by the actuarial method. On the whole, squamous cell carcinoma was the most favourable and anaplastic small cell carcinoma the least favourable lesion. However, in tumours smaller than 4 cm, confined to the lung and with negative lymph nodes (stage I), small cell carcinoma had the highest percentage of 5 year survivors, followed by large cell carcinoma, squamous cell carcinoma and adenocarcinoma. When tumours had attained a larger size and/or spread to neighbouring structures and regional lymph nodes (stage II and III), the histological type was a much more determining factor in survival, squamous cell carcinoma being a significantly more favourable lesion. On the other hand, no difference in survival in relation to the histological type was found when distant metastases were probably present (stage IV). It was concluded that in assessing the role of histopathology in the prognosis of lung cancer, the mutual relationship to other pathological factors must be taken into account.
28 citations
TL;DR: The epidermoid cancers had the lowest rates of pretherapeutic metastasis, the highest rates of operability and resectability, and the highest overall survival rates.
23 citations
01 Dec 1974
TL;DR: There was a significant difference in the survival of patients between invasion levels III and IV, but not between IV and V, and patients with small cell tumors had significantly less chance of survival than those with large cell tumors.
Abstract: A clinico-pathological study of 90 cases of stage-I malignant melanoma was made after a follow-up period of 2 to 16 years for the survivors, with an average follow-up period of 4.7 years, in an attempt to determine the prognostic significance of invasion level, chosen treatment plan, microscopic evidence of node involvement and predominant cytology of the tumor. Several important findings were made: there was a significant difference in the survival of patients between invasion levels III and IV, but not between IV and V ; immediate radical treatment was significantly more successful than either of the conservative methods investigated; the presence of microscopical deposits of tumor in nodes significantly worsened the prognosis; and patients with small cell tumors had significantly less chance of survival than those with large cell tumors.
7 citations