Showing papers on "Morphogen published in 1975"
TL;DR: The pattern of digits obtained is consistent with a model based on diffusion of a labile morphogen and is thus similar to models proposed for the development of pattern in invertebrates.
Abstract: The interpretation of positional information can provide the basis for pattern formation in limb morphogenesis. The gradient in positional information along the antero-posterior axis, which is specified with respect to a localised boundary region, can be modified by grafting this region to successive positions along the axis. The pattern of digits obtained is consistent with a model based on diffusion of a labile morphogen and is thus similar to models proposed for the development of pattern in invertebrates.
580 citations
TL;DR: The onset of a morphogenetic gradient and pattern formation are combined in a single coherent model and size invariance and its biological implications are discussed.
67 citations
TL;DR: A model for the differentiation (or the preceding determination) process that, using only localized cell to cell interactions, can approximate the cartilage pattern in any limb shape is proposed and gives a good approximation to the pattern of c cartilages found in the normal chick limb.
54 citations