Showing papers on "Red Meat Consumption published in 1998"
Journal Article•
TL;DR: It is suggested that polymorphisms in the NAT genes confer differential susceptibility to the effect of red meat consumption on colorectal cancer risk, especially among men 60 years old or older who were rapid acetylators for both NAT1 and NAT2.
Abstract: Carcinogenic heterocyclic amines are activated by N-acetyltransferase (NAT) enzymes, encoded by NAT1 and NAT2, to genotoxic compounds that can form DNA adducts in the colon epithelium. We have examined the relation of polymorphisms in the genes coding for both enzymes to risk of colorectal cancer and the gene-environment interaction with red meat intake among participants in the prospective Physicians' Health Study. Baseline blood samples from 212 men subsequently diagnosed with colorectal cancer during 13 years of follow-up were genotyped, along with 221 controls. NAT genotypes were analyzed by a PCR-restriction fragment length polymorphism method. Effect modification of the relation of red meat intake and risk of colorectal cancer by NAT genotype was assessed using conditional logistic regression. There was no overall independent association of NAT acetylation genotypes and colorectal cancer risk. The relative risks for the rapid acetylation genotype were 0.93 [95% confidence interval (CI), 0.61-1.42] for NAT1, 0.80 (95% CI, 0.53-1.19) for NAT2, and 0.81 (95% CI, 0.52-1.27) for NAT1/NAT2 combined. We observed a stronger association of red meat intake with cancer risk among NAT rapid acetylators, especially among men 60 years old or older. Among those men who were rapid acetylators for both NAT1 and NAT2, consumption of >1 serving of red meat per day was associated with a relative risk of 5.82 (95% CI, 1.11-30.6) compared with consumption of < or = 0.5 serving per day (P, trend = 0.02). These prospective data, which need to be confirmed in other studies, suggest that polymorphisms in the NAT genes confer differential susceptibility to the effect of red meat consumption on colorectal cancer risk.
242 citations
TL;DR: In large prospective studies, total fat intake has not been associated with risk of breast cancer, suggesting that international correlations are seriously confounded by differences in other variables related to affluence, including reproductive variables, physical activity, and food availability.
54 citations
TL;DR: The roles of attitudes to red meat (beef and lamb cuts) in red meat consumption were examined through a random postal survey in which nine hundred and three young Australians (aged 18 to 32 years) participated as discussed by the authors.
Abstract: The roles of attitudes to red meat (beef and lamb cuts) in red meat consumption were examined through a random postal survey in which nine hundred and three young Australians (aged 18 to 32 years) participated. Respondents completed a 42‐item Attitudes to Red Meat Questionnaire (ARMQ) derived from previous research. A combination of attitudinal and demographic variables accounted for almost one third of the variance in reported red meat consumption. Principal components analysis of ARMQ revealed a key sensory and social enjoyment attitude component, labelled “Appreciation,” which alone accounted for 20% of the red meat consumption variance. Additional attitude components included concerns about animal welfare, health restraint, organoleptic consequences and affordability‐convenience. Together, these attitude factors accounted for more variance than any combination of demographic items, although the meat consumption of men and women was found to be predicted by slightly different sets of attitudinal and de...
30 citations