Showing papers on "Renal medullary carcinoma published in 2005"
TL;DR: In young patients with sickle cell trait, an infiltrative renal mass with associated retroperitoneal adenopathy and caliectasis are characteristic findings of renal medullary carcinoma on CT and MRI.
Abstract: OBJECTIVE. We review the cross-sectional imaging findings of six cases of pathologically proven renal medullary carcinoma in patients with sickle cell trait. MRI findings were available in three of the patients. To our knowledge, only one previous report has addressed MRI features of this rare disease.CONCLUSION. In young patients with sickle cell trait, an infiltrative renal mass with associated retroperitoneal adenopathy and caliectasis are characteristic findings of renal medullary carcinoma on CT and MRI.
77 citations
TL;DR: The use of thalidomide or newer anti-angiogenesis agents should be considered for advanced disease and the role of ABL amplification with respect to etiology and as a therapeutic target should be investigated further.
75 citations
TL;DR: Two adolescents with metastatic disease who had significant responses to cisplatin or carboplatin in combination with gemcitabine and paclitaxel are described.
Abstract: Most patients with renal medullary carcinoma (RMC) have advanced disease at presentation and rarely respond to radiation or chemotherapy. We describe two adolescents with metastatic disease who had significant responses to cisplatin or carboplatin in combination with gemcitabine and paclitaxel.
52 citations
6 citations
Journal Article•
TL;DR: A 29 year-old Canadian male of Afro-Caribbean decent with sickle cell trait developed right-sided hemiparesis due to brain infarct and died suddenly 2 weeks after the presentation of massive non-neoplastic pulmonary thromboembolism, confirmed at autopsy.
Abstract: Renal medullary carcinoma is rare and extremely aggressive neoplasm that typically affects young patients of African decent who demonstrate sickle cell trait or disease. Since the original description in 1995, only few cases have been reported outside the United States. A 29 year-old Canadian male of Afro-Caribbean decent with sickle cell trait developed right-sided hemiparesis due to brain infarct. During the clinical work-up, a 3 cm renal tumor was detected in a horseshoe kidney. The patient died suddenly 2 weeks after the presentation of massive non-neoplastic pulmonary thromboembolism, confirmed at autopsy. The final diagnosis of renal medullary carcinoma was established after the autopsy. Due to the small size of the tumor and the limited metastatic spread only to the regional lymph nodes, the tumor was considered an incidental finding, and not the primary cause of patient's death.
2 citations
TL;DR: An 18-year-old Afro-Caribbean woman presented to her GP with a 2-week history of intermittent abdominal pain and was found to have microscopic haematuria and a laparotomy was carried out to make a definitive diagnosis before the start of chemotherapy.
Abstract: An 18-year-old Afro-Caribbean woman presented to her GP with a 2-week history of intermittent abdominal pain and was found to have microscopic haematuria. Her medical history was notable only for sickle cell trait. Examination was unremarkable and she was diagnosed as having a urinary tract infection. She re-presented with similar bouts of abdominal pain 2 months later and on clinical examination a large left supraclavicular lymph node was present. Excision biopsy of the lymph node raised the possibility of a metastatic renal tumour. Subsequent computed tomography imaging demonstrated a large 6 × 7 cm mass involving the upper part of the right kidney with extensive paracaval lymphadenopathy and encasement of the renal artery with metastasis to the liver, lung and ovaries (Figure 1). A laparotomy was carried out to make a definitive diagnosis before the start of chemotherapy. The tumour was found at multiple sites and was invading the inferior vena cava extending to the hepatic veins. Excision biopsy of th...
1 citations
01 Jan 2005
TL;DR: The patient was a 19-year-old adolescent who presented with right-sided flank pain who complained of weight loss, fatigue, dyspnea, and a non-productive cough, and the metastatic tumor demonstrated an aggressive and fatal course.
Abstract: Presented is a fatal case of renal medullary cancer (RMC) diagnosed in a woman with sickle cell trait. The patient was a 19-year-old adolescent who presented with right-sided flank pain. She complained of weight loss, fatigue, dyspnea, and a non-productive cough. The metastatic tumor demonstrated an aggressive and fatal course. Literature review of the pathology, histology, and metastatic potential of the tumor follows. No therapy has hitherto contributed to a prolonged disease-free survival. Int Pediatr. 2005;20(1):40-43.