Showing papers on "Rhinal sulcus published in 2008"
TL;DR: A single-branch, unbroken collateral sulcus is the predominant sulcal pattern found in temporal lobe epilepsy and may be an indicator of neurodevelopmental deviance associated with this condition.
Abstract: Background: We previously demonstrated that shape variants of the hippocampal formation are more prevalent in patients with temporal lobe epilepsy (TLE) than in healthy individuals. Objective: To categorize sulcal patterns of the basal temporal lobe in TLE compared to healthy controls. Methods: We studied 51 healthy controls and 69 patients with TLE (37 left, 32 right TLE). Brain sulci were identified and labeled automatically on MRI using an algorithm based on a congregation of neural networks that allows mapping three-dimensional sulcal models on the cortical surface. We used four sulcal patterns classes to categorize the sulcal arrangement in the inferior surface of the temporal lobe in each subject: Type 1, i.e., single-branch, unbroken collateral sulcus (CS) connected with the rhinal sulcus (RS) anteriorly; Type 2, i.e., CS connected with the occipitotemporal sulcus (OTS), but separated from the RS; Type 3, i.e., CS separated from the OTS and RS, which are connected; and Type 4, i.e., CS, OTS and RS separated. Results: In healthy controls, Type 1 and Type 2 were the patterns seen most frequently. Overall, 82% (42/51) of subjects had the same sulcal pattern in both temporal lobes. Inter-rater reliability for 35 randomly selected subjects indicated excellent agreement (Cohen’s Kappa: 0.84). Compared to controls, we found an increased frequency of Type 1 CS in patients with TLE, both in the left (77% vs 47%, p 0.004) and the right hemispheres (72% vs 41%, p 0.002). On the other hand, we found a decreased frequency of Type 2 CS in patients with TLE, both in the left (4% vs 31%, p 0.00002) and the right hemisphere (4% vs 35%, p 0.00001). Conclusions: A single-branch, unbroken collateral sulcus is the predominant sulcal pattern found in temporal lobe epilepsy. This “simplified” arrangement may be an indicator of neurodevelopmental deviance associated with this condition. Neurology ® 2008;70:2159–2165
41 citations
TL;DR: This work investigated the associative function of PC and EC with respect to sensory and motivational stimuli and the influence of the association on the neurocircuit and found activation of the deep layers of EC was sufficient to activate the dentate gyrus, suggesting the relevance of thedeep layers in cortico-hippocampal interactions.
39 citations