Showing papers on "Ribostamycin published in 1974"
TL;DR: This chapter discusses the structure and synthesis of aminoglycoside antibiotic, and the chemistry of individual sugars present in antibiotic has been reviewed along with sugars contained of other antibiotics.
Abstract: Publisher Summary This chapter discusses the structure and synthesis of aminoglycoside antibiotic. The chemistry of individual sugars present in antibiotic has been reviewed along with sugars contained of other antibiotics. The classification of aminoglycoside antibiotics has been based on common structural relationships, being divided into the seven groups discussed in the chapter. The modern instrumental techniques, particularly nuclear magnetic resonance (N.M.R.) spectroscopy, X-ray crystal-structure analysis, infrared (I.R.) spectroscopy, mass spectrometry (M.S.) are used. Studies on biochemical mechanisms of resistance to aminoglycoside antibiotics have revealed that they are enzymatically inactivated in several ways, and these mechanisms suggested that chemical modification of certain special groups of aminoglycoside molecules might lead to useful derivatives that would be active against resistant bacteria.
127 citations
TL;DR: A new aminoglycoside antibiotic was isolated from the fermentation broths of two strains of Bacillus species, and its antimicrobial spectrum is similar to that of ribostamycin, which is identical to the deacylated product obtained from butirosin A.
Abstract: A new aminoglycoside antibiotic was isolated from the fermentation broths of two strains of Bacillus species. The antibiotic is active against gram-positive and some gram-negative bacteria, and its antimicrobial spectrum is similar to that of ribostamycin. The chemical structure was determined to be 5-beta-d-xylofuranosylneamine, which is identical to the deacylated product obtained from butirosin A.
36 citations
TL;DR: It was found that the 5′′-hydroxy group of ribostamycin was preferentially phosphorylated by a cell-free extract from Pseudomonas aeruginosa GN 573, a clinical isolate.
Abstract: It was found that the 5′′-hydroxy group of ribostamycin was preferentially phosphorylated by a cell-free extract from Pseudomonas aeruginosa GN 573, a clinical isolate.
8 citations
TL;DR: In this article, the title compound was found to have an improved antibacterial spectrum broader than 3′,4′-dideoxyneamine and ribostamycin via 1,6-cyclic carbamate intermediates.
Abstract: The titled compound (5) has been prepared from 3′,4′-dideoxyneamine or ribostamycin via 1,6-cyclic carbamate intermediates (2 and 12). 3′,4′-Dideoxygenation, which is the key step in the synthesis from ribostamycin, was accomplished by the hydrogenation of 3′,4′-unsaturated derivative which was prepared from the corresponding 3′,4′-di-O-mesyl derivative by the action of sodium iodide and zinc dust in DMF. The title compound was found to have an improved antibacterial spectrum broader than 3′,4′-dideoxyneamine.
7 citations