Showing papers on "Super oxide dismutase published in 1998"
TL;DR: The finding that treatment with the enzyme preparation reduced tissue destruction leading to decreased formation offree radicals and subsequent effective scavenging of free radicals by the higher levels of enzymatic and non-enzymatic anti-oxidants is supported.
26 citations
Journal Article•
TL;DR: The result indicates that ofloxacin and dapsone have an antioxidant property, whereas clofazimine and rifampicin behave as pro-oxidants.
Abstract: The effect of ofloxacin (CAS 82419-36-1), dapsone (CAS 80-08-0), rifampicin (CAS 13282-46-1) and clofazimine (CAS 2030-63-9) on the generation of superoxide anions was studied in vitro. The drugs were incubated with a superoxide generating system (photochemical reaction between riboflavin and dianisidine). The change in optical density was measured. The optical density was increased with dapsone and ofloxacin and decreased in presence of clofazimine and rifampicin. This result indicates that ofloxacin and dapsone have an antioxidant property, whereas clofazimine and rifampicin behave as pro-oxidants.
17 citations
Patent•
15 Dec 1998
TL;DR: In this article, the authors present significant improvements for each event involved in the transplantation success or graft survival, including the reduction of early death of transplanted cells by anti-inflammatory agents such as TGFbeta1, an inhibitor of oligosaccharide synthesis, a glucosidase, IL-10, vIL-10.
Abstract: The present invention covers significant improvements for each event involved in the transplantation success or graft survival. These improvements, separately or combined with each other, greatly ameliorate the recovery of a tissue towards a normal function. They comprise: a) the reduction of early death of transplanted cells by anti-inflammatory agents such as TGFbeta1, an inhibitor of oligosaccharide synthesis, a glucosidase, IL-10, vIL-10, IL-4, INFgamma, IL-2R, IL-1Ra, Fas-L, sCR1, a super oxide dismutase, a neutrophil inhibitory factor (NIF), a ligand binding in an antagonist fashion to LFA-1, MAC-1, ICAM-1, CD-18, CD-31, CD-50, E-selectin, P-selectin, TNFalpha, IL-1 and IL-8. The anti-inflammatory agents may comprise an anti-LFA-1 or -ICAM-1; b) the improvement of the diffusion and of the fusion of transplanted cells with the host tissue by metalloproteases; c) the ex vivo proliferation of the transplanted cells with growth factors or oncogenes; d) the use of fibroblasts or stem cells in lieu of myoblasts, by transforming the formers into the latter with myogenic genes; e) expressing utrophin in lieu of dystrophin in cases of muscular dystrophy; and e) immunosuppressing the host for long-term graft survival.
11 citations
Journal Article•
TL;DR: SACS produces a significant antioxidant effect in atherogenic rats on lower dose of MSG, and reduced glutathione (GSH), SOD and Catalase levels were increased in liver, kidney and heart in rats on SACS.
Abstract: Objective : To study the effect of S-allyl cysteine sulphoxide (SACS) in rats on atherogenic diet with monosodium glutamate.
Methods : Rats on atherogenic diet with monosodium glutamate (MSG) at two doses received SACS for thirty days. At the end of thirty days malondialdehyde, hydroperoxide, conjugated diene and reduced glutathione content were estimated in the heart, liver, kidney, lung and brain. Super oxide dismutase (SOD) and catalase levels were analysed in heart, liver and kidney.
Results : SACS significantly decreased the concentration of malondialdehyde, hydroperoxides and conjugated diene in liver and heart in rats treated on MSG (250 mgkg). There were no significant changes observed by SACS in rats on MSG (1g/kg) as well as effect of SACS on MSG (250mg/kg) in lungs, kidney and brain. Reduced glutathione (GSH), SOD and Catalase levels were increased in liver, kidney and heart in rats on SACS.
Conclusion : SACS produces a significant antioxidant effect in atherogenic rats on lower dose of MSG.
9 citations