Showing papers on "Tartrazine published in 1983"

The significance of azo-reduction in the mutagenesis and carcinogenesis of azo dyes

Abstract: Azo dyes are widely used in textile, printing, cosmetic, drug and food-processing industries. They are also used extensively in laboratories as either biological stains or pH indicators. The extent of such use is related to the degree of industrialization. Since intestinal cancer is more common in highly industrialized countries, a possible connection may exist between the increase in the number of cancer cases and the use of azo dyes. Azo dyes can be reduced to aromatic amines by the intestinal microflora. The mutagenicity of a number of azo dyes is reviewed in this paper. They include Trypan Blue, Ponceau 3R, Pinceau 2R, Methyl Red, Methyl Yellow, Methyl Orange, Lithol Red, Orange I, Orange II, 4-Phenylazo-Naphthylamine, Sudan I, Sudan IV, Acid Alizarin Violet N, Fast Garnet GBC, Allura Red, Ponceau SX, Sunset Yellow, Tartrazine, Citrus Red No. 2, Orange B, Yellow AB, Carmoisine, Mercury Orange, Ponceau S, Versatint Blue, Phenylazophenol, Evan's Blue and their degraded aromatic amines. The significance of azo reduction in the mutagenesis and carcinogenesis of azo dyes is discussed.

Detection and Determination of Organic Impurities in Food Coal-Tar Dyes by High Performance Liquid Chromatograpy

Abstract: A systematic detection and determination method for organic impurities in 7 kinds of food coal-tar dyes (Tartrazine, Sunset Yellow FCF, Amaranth, New Coccine, Fast Green FCF, Brilliant Blue FCF and Indigo Carmine) was developed by the use of high performance liquid chromatography (HPLC) under the following operating conditions: Zipax SAX (strong anion exchange type resin) column; gradient elution system of 0.01M sodium borate solution and 0.1M sodium perchlorate solution; UV detection at 254nm as well as at the maximal absorbance wavelength of each dye. In order to try to introduce HPLC as a purity test in the Japanese Standards of Food Additives (JSFA), a regulation system for organic matter impurities is proposed based on total contents of starting material residues and uncombined intermediates expressed as the amount of sulphanilic acid, while total contents of subsidiary dyes were expressed as the amount of original dyes. By the use of the proposed method, a survey was carried out on 105 samples of coal-tar dyes that had passed the government product examination during 1978-1980.