Showing papers on "Toluidines published in 1986"

Identification and quantitative determination of aniline and toluidines in human urine

Abstract: Aniline and o-, m-, and p-toluidine, which are representative of aromatic amines in cigarette smoke, were identified and quantified in human urine. Smokers excreted 3.1 +/- 2.6 micrograms/24 h of aniline and 6.3 +/- 3.7 micrograms/24 h of o-toluidine (n = 16). Nonsmokers excreted 2.8 +/- 2.5 micrograms/24 h of aniline and 4.1 +/- 3.2 micrograms/24 h of o-toluidine (n = 12). Meta- and p-toluidine were detected in the urine of 2 of 11 smokers and 4 of 9 nonsmokers. The observed intra- and interindividual variations in the amounts of urinary aniline and o-toluidine were relatively large. The results of this study demonstrate for the first time that aniline and toluidines are present in human urine and suggest that sources other than cigarette smoke contribute significantly to their concentrations in urine.

Substituted toluidines, process for their preparation, pharmaceutical compositions containing them and their use as gastric secretion inhibitors

Abstract: o-Toluidine derivatives of the formula I in which A denotes S, SO or SO2 and R , R , R , R , R , R , R , R , R , R and R represent hydrogen and/or defined substituents.