Showing papers on "Treatment-resistant depression published in 1992"
7 citations
TL;DR: Three cases of severe depression in whom ECT was relatively contraindicated, who responded dramatically to switching lithium and fluoxetine to lithium and lofepramine, are reported.
Abstract: We report three cases of severe depression in whom ECT was relatively contraindicated, who responded dramatically to switching lithium and fluoxetine to lithium and lofepramine. Possible mechanisms are discussed.
4 citations
TL;DR: A review of the problems encountered and strategies used in the management of treatment-resistant depression (TRD) and its philosophy is however based on empirical concepts derived from day-to-day work.
Abstract: There were many commentaries following our review article. Some asked for a research/audit presentation of our clinical work which we had deliberately eschewed, aiming to put forward a review of the problems encountered and strategies used in the management of treatment-resistant depression (TRD). The review’s philosophy is however based on empirical concepts derived from our day-to-day work. The main points which we had wished to emphasize were:
3 citations
2 citations
TL;DR: A more realistic view of the TRD syndrome should encompass a broad spectrum of cases ranging from partial to complete drug resistance, and is in this context that this timely review on TRD by Malizia and Bridges is viewed.
Abstract: Treatment-resistant depression (TRD) is usually thought to characterize -10-15% of patients who are refractory to all conventional antidepressant therapy. However, in its broadest definition, TRD occurs across a spectrum of severity and is not an uncommon clinical problem, defining a sizeable portion of patients with mood disorders. Although the majority of treatment outcome studies report response rates to antidepressants in the 60-70% range, this figure should not be viewed as indicating the rate of remission, but rather an estimate of improvement from minimal response to complete remission. Thus, while as many as 60% of depressed patients may have some degree of response to antidepressant treatment, only ~ 25-30% of patients will achieve clinical remission. Therefore, estimates of response rate can hide the fact that most patients who are described as 'improved' with pharmacotherapy actually have a form of partial TRD. In this framework, a more realistic view of the TRD syndrome should encompass a broad spectrum of cases ranging from partial to complete drug resistance. It is in this context that we view this timely review on TRD by Malizia and Bridges.
1 citations