Showing papers on "Visceral leishmaniasis published in 1978"

The micro-ELISA technique in the serodiagnosis of visceral leishmaniasis

Abstract: The micro-scale Enzyme-linked Immunosorbent Assay (micro-ELISA) technique, with alkaline phosphatase as a marker enzyme, has been used for the serodiagnosis of human and canine visceral leishmaniasis, from foci in southern France. This technique which uses a soluble antigen is highly sensitive, with a degree of specificity slightly higher than that of the IFA. It is suggested that the micro-ELISA procedure can be added to the battery of serological techniques and would be particularly useful for large scale epidemiological studies of leishmaniasis.

Kala-azar among labour migrants in Metema-Humera region of Ethiopia.

Abstract: A semi-prospective study of clinical and laboratory data of kala-azar was made in 27 patients from Metema-Humera lowlands in north-west Ethiopia. Most patients were labour migrants. A high mortality rate (55.6%) was found in these labourers in spite of therapy with pentavalent antimonials. We suspect that kala-azar in this region is a zoonosis and believe that the clinical picture is similar to that of the Sudan.

Visceral leishmaniasis masquerading as a nasopharyngeal tumour. Report of a case.

Abstract: A 55-year-old male, a resident of a village in the foothills of the Himalayas in the north-western region of India, presented with a huge nasopharyngeal tumour but was subsequently found to be infected with Leishmania donovani, involving the nasopharyngeal tissue and the draining lymph nodes as well as a visceral infection.

Action of p-(4-amidino-phenoxy)-benzaldehyde-p-amidino-phenylhydrazone dihydrochloride on Leishmania donovani infections in the golden hamster.

Abstract: The chemotherapeutic effect of a new diamidine, HOE 668, the p-(4-amidino-phenoxy)-benzaldehyde-p-amidino-phenylhydrazone dihydrochloride, was compared with that of known anti-leishmanial drugs in golden hamsters infected with Leishmania donovani. The effect of HOE 668 against visceral leishmaniasis proved superior to that of pentamidine isethionate and the pentavalent antimonial drugs, sodium stibogluconate and N-methylglucamine antimoniate. However, HOE 668 can be used only experimentally because of its toxicity. Its very good anti-leishmanial action qualifies HOE 668 as a standard compound in screening tests.

The Diseases of the Country

Abstract: Certain methodological problems are likely to be encountered if observed disease occurrences based on hospital or other medical statistics are interpreted in a spatial geographical analysis. Epidemiological surveys of good quality—taking environmental factors into proper consideration—are scarce and usually restricted to a few diseases of major interest or importance and consequently generally very specific as opposed to aiming at spatial coverage.

Isoenzyme characterization of Leishmania spp from Algeria.

Abstract: Five Algerian stocks of Leishmania were compared with two stocks from USSR and one from Sudan by means of isoenzyme electrophoresis of two enzymes: glucose-phosphate isomerase (GPI) and phosphoglucomutase (PGM). Three stocks isolated from patients suffering from cutaneous leishmaniasis appeared to be L. tropica major. This correlated well the epidemiological features of the endemic area from where the stocks originated. Two stocks isolated from patients suffering from visceral leishmaniasis appeared to be different from the Sudanese stock of L. donovani.