A. A. Khutornenko

TL;DR: It is shown that a shutdown of mitochondrial respiration per se does not trigger p53 response, because inhibitors acting in the proximal and distal segments of the respiratory chain do not activate p53.

TL;DR: It is concluded that the exchange by cellular compartments between neural and stem cells improves MMSCs' protective abilities for better rehabilitation after stroke.

TL;DR: Regioselective synthesis, biological evaluation and 3D-molecular modeling for a series of novel diastereomeric 2-thioxo-5H-dispiro[imidazolidine-4, 3-pyrrolidine-2,3-indole]-2,5(1H)-diones are described.

TL;DR: It is shown that apoptosis in human colon carcinoma cells induced by the mitochondrial respiratory chain complex III inhibition can be prevented by supplementation with uridine or orotate rather than with dihydroorotate (a DHODH substrate), supported by the experiment showing that downregulation ofDHODH by RNA interference leads to accumulation of the p53 tumor suppressor and to apoptotic cell death.

TL;DR: It is concluded that a downregulation of mitochondrial ETC generally induces adaptive pro-survival responses, which are specifically abrogated by the suicidal p53 response triggered by the genetic risks of the pyrimidine nucleotide deficiency.