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Alexander G. Tonevitsky
Researcher at National Research University – Higher School of Economics
Publications - 178
Citations - 6361
Alexander G. Tonevitsky is an academic researcher from National Research University – Higher School of Economics. The author has contributed to research in topics: Ricin & Gene. The author has an hindex of 36, co-authored 165 publications receiving 5129 citations. Previous affiliations of Alexander G. Tonevitsky include Russian Academy & Martin Luther University of Halle-Wittenberg.
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Journal ArticleDOI
A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture
Ilka Wagner,Eva-Maria Materne,Sven Brincker,Ute Süßbier,Caroline Frädrich,Mathias Busek,Mathias Busek,Frank Sonntag,D. A. Sakharov,E. V. Trushkin,Alexander G. Tonevitsky,Roland Lauster,Uwe Marx +12 more
TL;DR: A multi-organ-chip capable of maintaining 3D tissues derived from cell lines, primary cells and biopsies of various human organs is presented, providing a potential new tool for systemic substance testing.
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Structural Basis for the Function of the Ribosomal L7/12 Stalk in Factor Binding and GTPase Activation
Mihaela Diaconu,Ute Kothe,Frank Schlünzen,Niels Fischer,J. Harms,Alexander G. Tonevitsky,Holger Stark,Marina V. Rodnina,Markus C. Wahl +8 more
TL;DR: In this paper, the L7/12 stalk of the large subunit of bacterial ribosomes is organized into three elements (stalk base, L10 helix α8-L7/ 12 N-terminal-domain complex, and L 7/12 Cterminal domains) linked by flexible connections.
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Circulating miRNAs: Cell-cell communication function?
TL;DR: The state-of-the-art in the field of intercellular miRNA transport is discussed and current theories regarding the origin and the biological function of extracellular miRNAs are highlighted.
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Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing.
Uwe Marx,Tommy B. Andersson,Anthony Bahinski,Mario Beilmann,Sonja Beken,Flemming R. Cassee,Murat Cirit,Mardas Daneshian,Susan Fitzpatrick,Olivier Frey,Claudia Gaertner,Christoph Giese,Linda G. Griffith,Thomas Hartung,Minne B. Heringa,Julia Hoeng,Wim H. de Jong,Hajime Kojima,Jochen Kuehnl,Marcel Leist,Andreas Luch,Ilka Maschmeyer,D. A. Sakharov,Adriënne J.A.M. Sips,Thomas Steger-Hartmann,Danilo A. Tagle,Alexander G. Tonevitsky,Tewes Tralau,Sergej Tsyb,Anja van de Stolpe,Rob J. Vandebriel,Paul Vulto,Jufeng Wang,Joachim Wiest,Marleen Rodenburg,Adrian Roth +35 more
TL;DR: The status quo of microphysiological systems available today against industry needs is reviewed, and the broad variety of approaches with fit-for-purpose potential in the drug development cycle are assessed, and feasibility solutions to reach the next levels of human biology in vitro are proposed.
Journal ArticleDOI
Latrophilin 1 and its endogenous ligand Lasso/teneurin-2 form a high-affinity transsynaptic receptor pair with signaling capabilities
John-Paul Silva,Vera G. Lelianova,Yaroslav S. Ermolyuk,Nickolai Vysokov,Paul G. Hitchen,Otto Berninghausen,M. Atiqur Rahman,Alice Zangrandi,Sara Fidalgo,Alexander G. Tonevitsky,Anne Dell,Kirill E. Volynski,Yuri A. Ushkaryov +12 more
TL;DR: Immunoblotting and immunoelectron microscopy of purified synapses and immunostaining of cultured hippocampal neurons show that LPH1 and Lasso are enriched in synapses; in both systems, L PH1 is presynaptic, whereas Lasso is postsynaptic.