A Ahmadi

TL;DR: It is concluded that CP-induced toxic effects on androgenesis and spermatogenesis is mediated by free radicals and SKEO protects reproductive system from toxicity of CP through its antioxidant potential and androgenic activity.

TL;DR: Examination of ovarian functionality and oxidative response in hyperandrogenism-induced polycystic ovary and the protective effects of immunomodulator drug (IMOD) provided evidence that toxic free radicals and TNF-α were involved in the pathogenesis of PCO and prevented ovarian histopathologic, endocrine, and biochemical alterations induced by hyper androgenism.

TL;DR: Results indicate that PIO is able to exert direct antioxidative and anti-inflammatory effects on the endocrine, biochemical, and pathological alterations independent of its possible effects mediated via increased insulin sensitivity in hyperandrogenized PCO.

TL;DR: It appears necessary to use higher amikacin dosage (≥ 25 mg/kg) considering hemodynamic response of patients to sepsis, and a close drug monitoring and a shift from the population mean toward a value more representative of the critically ill patient subpopulation is crucial.

TL;DR: Results of this study suggest that IL-6 and APACHE II are useful cytokine and scoring systems respectively in prediction of mortality and clinical evaluation of severe septic patients.