A
A. GonzÃlez FernÃndez
Researcher at Laboratory of Molecular Biology
Publications - 1
Citations - 247
A. GonzÃlez FernÃndez is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Somatic hypermutation & Affinity maturation. The author has an hindex of 1, co-authored 1 publications receiving 246 citations.
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Targeting of non-Ig sequences in place of the V segment by somatic hypermutation.
J. Yélamos,Norman Klix,Beatriz Goyenechea,Francisco Lozano,Y. L. Chui,A. GonzÃlez FernÃndez,Richard Pannell,Michael S. Neuberger,Cesar Milstein +8 more
TL;DR: It is shown, using mice containing single or multiple transgene constructs, that an immunoglobulin VK segment can be replaced by human β-globin or prokaryotic neo or gpt genes without affecting the rate of hypermutation; the V gene itself is not necessary for recruiting hypermutations.