M
Michael S. Neuberger
Researcher at Laboratory of Molecular Biology
Publications - 140
Citations - 25097
Michael S. Neuberger is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Somatic hypermutation & Antibody. The author has an hindex of 80, co-authored 139 publications receiving 24453 citations.
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Journal ArticleDOI
Replacing the complementarity-determining regions in a human antibody with those from a mouse
TL;DR: This work substituted the CDRs from the heavy-chain variable region of mouse antibody B1–8, which binds the hapten NP-cap, for the corresponding CDRs of a human myeloma protein, to determine whether the antigen-binding site could be transplanted from one framework to another by grafting theCDRs.
PatentDOI
DNA deamination mediates innate immunity to (retro)viral infection
Michael H. Malim,Ann M. Sheehy,Reuben S. Harris,Kate Bishop,Michael S. Neuberger,Nathan Gaddis,James H. M. Simon +6 more
TL;DR: Evidence is provided that CEM15/APOBEC3G is a DNA deaminase that is incorporated into virions during viral production and subsequently triggers massive deamination of deoxycytidine to deoxyuridine within the retroviral minus (first)-strand cDNA, thus providing a probable trigger for viral destruction.
Journal ArticleDOI
AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification
TL;DR: It is shown that expression of AID in Escherichia coli gives a mutator phenotype that yields nucleotide transitions at dC/dG in a context-dependent manner, which indicates that AID functions by deaminating dC residues in DNA.
Journal ArticleDOI
Comparison of the effector functions of human immunoglobulins using a matched set of chimeric antibodies.
Marianne Brüggemann,Gareth T. Williams,C Bindon,Mike Clark,M R Walker,R Jefferis,Herman Waldmann,Michael S. Neuberger +7 more
TL;DR: The results suggest that IgG1 might be the favoured IgG subclass for therapeutic applications in complement-dependent hemolysis and in antibody-dependent cell-mediated cytotoxicity using both human effector and human target cells.
Journal ArticleDOI
Recombinant antibodies possessing novel effector functions
TL;DR: Cell lines have been established that secrete hapten-specific antibodies in which the Fc portion has been replaced either with an active enzyme moiety or with polypeptide displaying c-myc antigenic determinants.