Catalyst-free reactions developed during the last decade and the latest developments in this emerging field are summarized with a focus on catalyst-free reactions in-water and on-water. Various named reactions, multi-component reactions and the synthesis of heterocyclic compounds are discussed including the use of various energy input systems such as microwave- and ultrasound irradiation, among others. Organic chemists and the practitioners of this art both in academia and industry hopefully will continue to design benign methodologies for organic synthesis in aqueous media under catalyst-free conditions by using alternative energy inputs based on fundamental principles.

Benign by design: catalyst-free in-water, on-water green chemical methodologies in organic synthesis

Synthesis of 2-substituted-benzothiazoles by palladium-catalyzed intramolecular cyclization of o-bromophenylthioureas and o-bromophenylthioamides

Solid-Phase Synthesis of 2-Aminothiazoles.

A mild and efficient method for the preparation of guanidines

Cationic phosphine ligands containing m-guanidinium phenyl substituents {Ph3-nP[C6H4-m-NHC(NH2)(NMe2)]n}n+ nCl- (n = 1−3) (17a−c) have been obtained by addition of dimethylcyanamide to the amino gr...

Water Soluble Cationic Phosphine Ligands Containing m-Guanidinium Phenyl Moieties. Syntheses and Applications in Aqueous Heck Type Reactions.

Deux voies d'acces aux composes du titre: reaction de derives d'aniline avec l'isothiocyanate de l'acide benzoique suivie d'hydrolyse basique ou reaction d'ammoniac avec des isothiocyanates

A. J. Molinari

Papers

Improved Procedures for the Preparation of Cycloalkyl-, Arylalkyl-, and Arylthioureas

A versatile synthesis of novel N,N,N″-trisubstituted guanidines

Improved Procedures for the Preparation of Cycloalkyl-, Arylalkyl-, and Arylthioureas.

A Versatile Synthesis of Novel N,N,N′′-Trisubstituted Guanidines.

2-pyrrolidinylideneureas, a new class of central nervous system agents