Journal ArticleDOI
A versatile synthesis of novel N,N,N″-trisubstituted guanidines
C. R. Rasmussen,F. J. Villani,B. E. Reynolds,J. N. Plampin,A. R. Hood,L. R. Hecker,S. O. Nortey,A. Hanslin,M. J. Costanzo,R. M. Howse,A. J. Molinari +10 more
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This article is published in Synthesis.The article was published on 1988-01-01. It has received 39 citations till now.read more
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A mild and efficient method for the preparation of guanidines
TL;DR: A mild and efficient method for the preparation of guanidines by reaction of an acylated thiourea with an amine followed by removal of the acyl group(s) from the intermediate acylguanidine is reported.
Journal ArticleDOI
Water Soluble Cationic Phosphine Ligands Containing m-Guanidinium Phenyl Moieties. Syntheses and Applications in Aqueous Heck Type Reactions.
TL;DR: A comparative study of 17b and 17c, the aryl alkyl guanidinium phosphines 18 and 19, and TPPTS in the aqueous phase palladium-catalyzed C-C coupling reaction between p-iodobenzoate and (trifluoroacetyl)propargylamine shows 17b to be of surmounting activity.
Journal ArticleDOI
Cobalt(II)-Catalyzed Synthesis of Sulfonyl Guanidines via Nitrene Radical Coupling with Isonitriles: A Combined Experimental and Computational Study
TL;DR: A Co(II)-catalyzed synthesis of sulfonyl guanidines by using amines, isonitriles, and organic azides as nitrene sources has been developed as discussed by the authors.
Journal ArticleDOI
Solid phase synthesis of oligomeric guanidiniums
TL;DR: In this paper, four routes for stepwise solid phase synthesis of guanidinium linkages were described, and aza-Wittig couplings were used to produce guaninium from resin-bound carbodiimides.
Journal ArticleDOI
NG‐Acylated Aminothiazolylpropylguanidines as Potent and Selective Histamine H2 Receptor Agonists
Anja Kraus,Prasanta Ghorai,Tobias Birnkammer,David Schnell,Sigurd Elz,Roland Seifert,Stefan Dove,Günther Bernhardt,Armin Buschauer +8 more
TL;DR: It is shown that bioisosteric replacement of the imidazole ring in NG‐acylatedImidazolylpropylguanidines by a 2‐aminothiazol‐5‐yl group resulted in potent H2R agonists with much greater selectivity for the human H2 R over H3 and H4 receptors.