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A.J.P. Klein-Szanto
Researcher at University of Texas System
Publications - 9
Citations - 129
A.J.P. Klein-Szanto is an academic researcher from University of Texas System. The author has contributed to research in topics: Squamous metaplasia & SENCAR Mouse. The author has an hindex of 6, co-authored 9 publications receiving 129 citations. Previous affiliations of A.J.P. Klein-Szanto include Fox Chase Cancer Center.
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Malignant progression of mouse skin papillomas treated with ethylnitrosourea, N-methyl-N'-nitro-N-nitrosoguanidine, or 12-O-tetradecanoylphorbol-13-acetate.
TL;DR: Enhanced progression of benign skin tumors in mice by only a few treatments of an agent may serve as a potential model for studies into the mechanisms and the inhibition of malignant progression and for a comparison of the potency of agents in enhancing malignant progress.
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The fust stage and complete promoting activity of retinoic acid but not the analog RO-10-9359
TL;DR: Comparisons revealed that retinoic acid alone can induce dark keratinocytes, a characteristic of tumor promoters, while RO-10-9359 cannot, and the data suggest that the ability of retinoids but not RO- 10- 9359 to promote tumors and induce dark cells may be due to initial oxidative reactions at the cell membrane.
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Epidermoid metaplasias of xenotransplanted human tracheobronchial epithelium.
TL;DR: The hyperplastic nature of these carcinogen-induced lesions, together with the presence of cellular atypia and an altered involucrin distribution pattern, suggest a preneoplastic state.
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Metastasis from squamous cell carcinomas of SENCAR mouse skin produced by complete carcinogenesis.
TL;DR: The incidence of metastasis was evaluated in female SENCAR mice after induction of squamous cell carcinomas by repetitive applications of either benzo [a] pyrene (B] P or N-methyl-N'-nitro-N-nitrosogaunidine (MNNG) and the major site of metastases was the lungs; however, metastatic tumors were also found in lymph nodes, adrenal glands and kidneys.
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Retinoyl-phorbol-acetate is a complete skin tumor promoter in SENCAR mice.
TL;DR: In SENCAR mice, RPA has moderate complete promoting activity as well as second stage activity, and induces epidermal hyperplasia and an increase in the number of dark basal keratinocytes.