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Thomas J. Slaga
Researcher at University of Texas System
Publications - 385
Citations - 14710
Thomas J. Slaga is an academic researcher from University of Texas System. The author has contributed to research in topics: DMBA & Tumor promotion. The author has an hindex of 62, co-authored 365 publications receiving 14448 citations. Previous affiliations of Thomas J. Slaga include Wistar Institute & Yale University.
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Journal ArticleDOI
Skin tumor-promoting activity of benzoyl peroxide, a widely used free radical-generating compound
TL;DR: A single topical application of benzoyl peroxide produced a marked epidermal hyperplasia and induced a large number of dark basal keratinocytes, effects similar to those produced by the potent tumor promoter 12-O-tetradecanoyl phorbol-13-acetate.
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Studies on the mechanism of skin tumor promotion: evidence for several stages in promotion.
TL;DR: Although mezerein by itself is a weak promoter and mimics TPA in many biochemical and morphological effects it is a potent second-stage promoter in a two-stage promotion regimen, the results suggest that 4-O-methyl-TPA had weak activity as a first-stage promoters.
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The role of IKK in constitutive activation of NF-κB transcription factor in prostate carcinoma cells
Alexander V. Gasparian,Ya Juan Yao,Dariusz Kowalczyk,Ludmila A. Lyakh,Apollon Karseladze,Thomas J. Slaga,Irina Budunova +6 more
TL;DR: The data suggest that increased IKK activation leads to the constitutive activation of NF-kappaB 'survival signaling' pathway in androgen-independent PC cells, important for the support of their androgens-independent status and growth advantage.
Journal Article
Marked Differences in the Skin Tumor-initiating Activities of the Optical Enantiomers of the Diastereomeric Benzo(a)pyrene 7,8-Diol-9,10-Epoxides
Thomas J. Slaga,W. J. Bracken,G. Gleason,Wayne Levin,Haruhiko Yagi,D M Jerina,Allan H. Conney +6 more
TL;DR: The data suggest that (+)-7β,8α-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo( a )pyrene is an ultimate carcinogenic form of benzo(A)pyrene, which is found to be greater when given daily at a dose of 34 nmol/day than when given once at a 200-nmol dose level.
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Phorbol esters stimulate DNA synthesis and ornithine decarboxylase activity in mouse epidermal cell cultures
Stuart H. Yuspa,Ulrike Lichti,Theresa Ben,Elroy Patterson,Henry Hennings,Thomas J. Slaga,Nancy Colburn,William H. Kelsey +7 more
TL;DR: Evidence from the laboratory indicates that brief exposure to the potent phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA), stimulates DNA synthesis and ODC activity in mouse epidermal cell cultures.