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A.L. de Weck
Researcher at University of Navarra
Publications - 164
Citations - 6134
A.L. de Weck is an academic researcher from University of Navarra. The author has contributed to research in topics: Immunoglobulin E & Antigen. The author has an hindex of 37, co-authored 164 publications receiving 6022 citations. Previous affiliations of A.L. de Weck include University of Bern.
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Journal ArticleDOI
Diagnosis of immediate allergic reactions to beta‐lactam antibiotics
María José Torres,Miguel Blanca,Javier Fernández,Antonino Romano,A.L. de Weck,Werner Aberer,Knut Brockow,Werner J. Pichler,Pascal Demoly +8 more
TL;DR: Allergic reactions to betalactams are the most common cause of adverse drug reactions mediated by specific immunological mechanisms and the number of reactions has not decreased, although the production process of betAlactams has improved over the years.
Journal Article
Nature and extent of penicillin side-reactions, with particular reference to fatalities from anaphylactic shock.
TL;DR: An appraisal is made of toxic, microbiogenic, and allergic side effects occurring in man as a result of large amounts of penicillin increasingly used in medical and veterinary practice, including a study of 151 anaphylactic fatalities reported to have followedPenicillin administration.
Journal ArticleDOI
Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) - classification, diagnosis and management: review of the EAACI/ENDA(#) and GA2LEN/HANNA*.
Marek L. Kowalski,Joanna Makowska,Miguel Blanca,Sevim Bavbek,Grazyna Bochenek,Jean Bousquet,Philippe-Jean Bousquet,Gülfem Çelik,Pascal Demoly,Eva Rebelo Gomes,Ewa Nizankowska-Mogilnicka,Antonino Romano,Mario Sánchez-Borges,Maria L. Sanz,María José Torres,A.L. de Weck,Andrzej Szczeklik,Knut Brockow +17 more
TL;DR: Hypersensitivity to nonsteroidal anti‐inflammatory drugs (NSAIDs) – classification, diagnosis and management: Review of the EAACI/ENDA and GA2LEN/HANNA is reviewed.
Journal ArticleDOI
Flow cytometric basophil activation test by detection of CD63 expression in patients with immediate-type reactions to betalactam antibiotics.
Maria L. Sanz,Pedro M. Gamboa,I. Antépara,C. Uasuf,Vila L,García-Avilés C,M. Chazot,A.L. de Weck +7 more
TL;DR: In this paper, the authors used flow cytometry to determine the percentage of activated basophils that expressed the CD63 marker after in vitro stimulation by different betalactam antibiotics.
Journal ArticleDOI
Interleukin 3-dependent mediator release in basophils triggered by C5a.
TL;DR: IL-3 is a potent modifier of effector functions of mature basophils; this is possibly of greater in vivo significance than its growth factor properties and this might be important in the pathogenesis of immediate type hypersensitivity reactions, shock syndromes, and inflammation.