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A. M. Rowland
Researcher at Genentech
Publications - 3
Citations - 3205
A. M. Rowland is an academic researcher from Genentech. The author has contributed to research in topics: Antigen & Patch clamp. The author has an hindex of 2, co-authored 2 publications receiving 3126 citations.
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Journal ArticleDOI
Humanization of an anti-p185HER2 antibody for human cancer therapy.
Paul Carter,L. G. Presta,Cornelia M. Gorman,John B. Ridgway,Dennis J. Henner,Wai Lee Wong,A. M. Rowland,Claire Kotts,M. E. Carver,H M Shepard +9 more
TL;DR: The murine monoclonal antibody mumAb4D5, directed against human epidermal growth factor receptor 2 (p 185HER2), specifically inhibits proliferation of human tumor cells overexpressing p185HER2, but the efficacy of mumAb 4D5 in human cancer therapy is likely to be limited by a human anti-mouse antibody response and lack of effector functions.
Journal ArticleDOI
High level Escherichia coli expression and production of a bivalent humanized antibody fragment.
Paul Carter,Robert F. Kelley,M L Rodrigues,Brad Snedecor,M. Covarrubias,Velligan,Wai Lee Wong,A. M. Rowland,Claire Kotts,M. E. Carver +9 more
TL;DR: A protocol is developed to directly and efficiently recover Fab′ with the single hinge cysteine in the free thiol state, allowing F(ab′)2 formation by chemically-directed coupling in vitro, and makes E. coli expression of bivalent antibody fragments for human therapy (or other uses) practical.
Journal ArticleDOI
Characterisation of C101248: A novel selective THIK-1 channel inhibitor for the modulation of microglial NLRP3-inflammasome
Bernardino Ossola,Ali Rıfat,A. M. Rowland,Helen Hunter,Samuel Drinkall,Clare Bender,Mayida Hamlischer,Martin Richard Teall,Russell Burley,Daniella M. Barker,D. A. Cadwalladr,Louise Dickson,Jason Lawrence,Jenna Harvey,Marina Lizio,Xiao Xu,Edel Kavanagh,Toni Cheung,Steven A. Sheardown,Catherine B. Lawrence,Michael F Harte,David Brough,Christian Madry,Kim L. Matthews,Kevin J. Doyle,Keith L. Page,Justin J W Powell,N. L. Brice,Roland Bürli,Mark B. L. Carlton,Lee A. Dawson +30 more
TL;DR: In this paper , a selective small-molecule inhibitor of the K+ channel 1 (THIK-1) was proposed to prevent the NLRP3-dependent release of IL-1β from microglia.