C
Catherine B. Lawrence
Researcher at University of Manchester
Publications - 75
Citations - 4262
Catherine B. Lawrence is an academic researcher from University of Manchester. The author has contributed to research in topics: Inflammasome & Stroke. The author has an hindex of 35, co-authored 69 publications receiving 3550 citations. Previous affiliations of Catherine B. Lawrence include Manchester Academic Health Science Centre.
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Acute central ghrelin and GH secretagogues induce feeding and activate brain appetite centers.
TL;DR: Using c-Fos immunohistochemistry, it is demonstrated that icv ghrelin or GHRP-6 activated several hypothalamic brain regions, including the arcuate nucleus, paraventricular nucleus, dorsomedial nucleus, lateral hypothalamus, and two regions of the brainstem, the nucleus of the tractus solitarius and the area postrema.
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Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models.
Michael J.D. Daniels,Jack Rivers-Auty,Tom Schilling,Nicholas G. Spencer,William Watremez,Victoria Fasolino,Sophie J. Booth,Claire S. White,Alex G. Baldwin,Sally Freeman,Raymond C.B. Wong,Clare H Latta,Shi Yu,Joshua Jackson,Nicolas Fischer,Violette Koziel,Thierry Pillot,James Bagnall,Stuart M. Allan,Pawel Paszek,James Galea,Michael K. Harte,Claudia Eder,Catherine B. Lawrence,David Brough +24 more
TL;DR: It is shown that several clinically approved and widely used NSAIDs of the fenamate class are effective and selective inhibitors of the NLRP3 inflammasome via inhibition of the volume-regulated anion channel in macrophages, independently of COX enzymes.
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Alternative role for prolactin-releasing peptide in the regulation of food intake.
TL;DR: A reduction in the expression of Pr RP mRNA during lactation and fasting and an acute effect of PrRP on food intake and body weight are shown, supporting the hypothesis of an alternative role for the peptide.
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High-fat diet-induced memory impairment in triple-transgenic Alzheimer's disease (3xTgAD) mice is independent of changes in amyloid and tau pathology.
TL;DR: It is indicated that a high-fat diet has rapid and long-lasting negative effects on memory in both control and AD mice that are associated with neuroinflammation, but independent of changes in beta amyloid and tau neuropathology in the AD mice.
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Interleukin-1beta and the interleukin-1 receptor antagonist act in the striatum to modify excitotoxic brain damage in the rat
TL;DR: Novel actions of IL‐1 in the Striatum are revealed which markedly exacerbate cortical neuronal damage elicited by local excitotoxins in the striatum or cortex.