P
Paul Carter
Researcher at Genentech
Publications - 151
Citations - 27141
Paul Carter is an academic researcher from Genentech. The author has contributed to research in topics: Antibody & Antigen. The author has an hindex of 67, co-authored 150 publications receiving 26065 citations. Previous affiliations of Paul Carter include University of California, San Francisco & Seattle Genetics.
Papers
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Journal ArticleDOI
Humanization of an anti-p185HER2 antibody for human cancer therapy.
Paul Carter,L. G. Presta,Cornelia M. Gorman,John B. Ridgway,Dennis J. Henner,Wai Lee Wong,A. M. Rowland,Claire Kotts,M. E. Carver,H M Shepard +9 more
TL;DR: The murine monoclonal antibody mumAb4D5, directed against human epidermal growth factor receptor 2 (p 185HER2), specifically inhibits proliferation of human tumor cells overexpressing p185HER2, but the efficacy of mumAb 4D5 in human cancer therapy is likely to be limited by a human anti-mouse antibody response and lack of effector functions.
Patent
A method for making heteromultimeric polypeptides
TL;DR: In this article, the authors proposed a method of preparing heteromultimeric polypeptides by replacing small amino acid side chains from the interface with larger side chains (e.g. tyrosine or tryptophan).
Patent
Method for making humanized antibodies
Paul Carter,Leonard G. Presta +1 more
TL;DR: In this article, the authors provide a detailed discussion of the use of humanized antibody polypeptides and methods for their preparation and use, along with consensus immunoglobulin sequences and structural models.
Journal ArticleDOI
Potent antibody therapeutics by design
TL;DR: The generation of potent antibody therapeutics, which I review here, is an iterative design process that involves the generation and optimization of antibodies to improve their clinical potential.
Journal ArticleDOI
Hydrogen bonding and biological specificity analysed by protein engineering
Alan R. Fersht,Jian-Ping Shi,J.W. Knill-Jones,Denise M. Lowe,Anthony J. Wilkinson,David M. Blow,Peter Brick,Paul Carter,Mary M.Y. Waye,Greg Winter +9 more
TL;DR: The role of complementary hydrogen bonding as a determinant of biological specificity has been examined by protein engineering of the tyrosyl-tRNA synthetase and the presence of an unpaired and charged donor or acceptor weakens binding energy.