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A. S. Golubev
Researcher at A. N. Nesmeyanov Institute of Organoelement Compounds
Publications - 39
Citations - 265
A. S. Golubev is an academic researcher from A. N. Nesmeyanov Institute of Organoelement Compounds. The author has contributed to research in topics: Trifluoromethyl & Amino acid. The author has an hindex of 11, co-authored 33 publications receiving 246 citations. Previous affiliations of A. S. Golubev include Ludwig Maximilian University of Munich & Russian Academy of Sciences.
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Journal ArticleDOI
A New Strategy for the Synthesis of alpha-Difluoromethyl-Substituted alpha-Hydroxy and alpha-Amino Acids.
Sergey N. Osipov,A. S. Golubev,Norbert Sewald,Thomas Michel,Alexey F. Kolomiets,and Alexander V. Fokin,K. Burger +6 more
TL;DR: A new method for the preparation of alpha-chlorodifluoromethyl, alpha-bromodif LU-substituted alpha-hydroxy and alpha-amino acid esters 11, 19-21 is described, which provides the corresponding free amino acids 25, 26, 28.
Journal ArticleDOI
Synthesis and some heterocyclisation reactions of CF2H-and CF2Cl-substituted 1,1-dicyanoethylenes
A. S. Golubev,P. V. Pasternak,Alexander F. Shidlovskii,Ljudmila N. Saveleva,Boris B. Averkiev,V. N. Nesterov,Michail Yu. Antipin,Alexander S. Peregudov,N. D. Chkanikov +8 more
TL;DR: In this article, new CF2X-analogues of 1,1-dicyano-2,2-bis(trifluoromethyl)ethylene (1) (X=H, Cl) were synthesised by the condensation of polyfluoroketones with malononitrile followed by dehydration using thionyl chloride (or phosphorus pentoxide).
Journal Article
Synthesis of ϒ-Oxo α-Amino Acids from L-Aspartic Acid
TL;DR: In this paper, the synthesis of different α-amino acids from hexafluoroacetone protected L-aspartic acid chloride via Stille cross coupling reaction is described.
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Trifluoromethyl-substituted hydantoins, versatile building blocks for rational drug design
TL;DR: Preparatively simple, one-pot syntheses of trifluoromethyl-substituted hydantoins starting from Boc-protected imines of hexafluoroacetone and trifloropyruvate are described, representing valuable building blocks for the construction of constrained peptides or for the synthesis of highly potent VLA-4 antagonists.
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New efficient syntheses of α-diflyoromethyl- and α-trifluoromethyl-ornithine
TL;DR: In this article, a new efficient method for the preparation of ornithine derivatives was described, where the key step of the synthesis is the regioselective alkylation of imine 2 with propargyl amine 1.