Use of rauwolfia serpentina benth. in neuropsychiatric conditions

Pathways of glucose catabolism1

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The enzymic synthesis of trehalose phosphate1

A concise preparation of optically active l or d-6-methoxytryptophan ethyl ester 21 was developed via the Fischer indole/Schollkopf protocol from 6-methoxy-3-methylindole 16 (four steps, 58% overall yield). This method was extended to the enantiospecific total synthesis of tryprostatin A (11) via a regiospecific bromination process as a key step. In addition, 6-methoxy-2-bromotryptophan ethyl ester (32), a potential intermediate for indole alkaloid synthesis, was prepared via this strategy.

Enantiospecific Synthesis of Optically Active 6-Methoxytryptophan Derivatives and Total Synthesis of Tryprostatin A1

Cytotoxic indole alkaloids from Tabernaemontana officinalis.

Es wird die Isolierung eines neuen Alkaloids aus Rauwolfia serpentina Benth. beschrieben. Das schwach basische Alkaloid, das mit Sarpagin bezeichnet wurde, besitzt die Bruttoformel C19H22O2N2 und bildet mit Sauren bestandige kristallisierte Salze von der Zusammensetzung C19H22O2N2, HX.

A. Stoll

Papers

Sarpagin, ein neues Alkaloid aus Rauwolfia serpentina Benth