A. V. Hoffbrand

TL;DR: 14 patients were given marrows virtually depleted of identifiable donor marrow T lymphocytes by the use of a "cocktail" of specific anti-T-cell monoclonal antibodies (MBG6 and RFT8) and rabbit complement and GvHD was totally prevented.

TL;DR: This work reports prolonged survival of purified CLL cells cultured on bone marrow (BM) derived stromal cells in the absence of exogenous growth factors and provides an in vitro system that can be used to analyse the growth requirements of C LL cells and their chemosensitivity in an in vivo environment that mimics the in vivo milieu.

TL;DR: A fundamental difference between the genetics of ALL in most older and the majority of younger patients may partly explain the increasingly poor prognosis with age.

TL;DR: Recipients of seronegative marrow had a fifteen-fold greater risk of CMV pneumonitis and a fifty-fold increase in risk of a fatal CMV infection than recipients of seropositive marrow; whenever possible, such recipients should be given marrow from ser onegative donors.

TL;DR: The data show that quantitation of liver iron from a single liver biopsy has little value in long‐term monitoring of iron stores, and most complications can be avoided if ferritin levels can be brought down to <1500 μg/l.