A
A W Tam
Researcher at Genentech
Publications - 3
Citations - 4565
A W Tam is an academic researcher from Genentech. The author has contributed to research in topics: Peptide sequence & Cell surface receptor. The author has an hindex of 3, co-authored 3 publications receiving 4484 citations.
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Journal ArticleDOI
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells
Axel Ullrich,Lisa M. Coussens,Joel S. Hayflick,Thomas J. Dull,Alane M. Gray,A W Tam,Jeffrey E. Lee,Yosef Yarden,Towia A. Libermann,Joseph Schlessinger +9 more
TL;DR: The complete 1,210-amino acid sequence of the human epidermal growth factor (EGF) receptor precursor, deduced from cDNA clones derived from placental and A431 carcinoma cells, reveals close similarity between the entire predicted ν-erb-B mRNA oncogene product and the receptor transmembrane and cytoplasmic domains.
Journal ArticleDOI
Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.
Axel Ullrich,Alane M. Gray,A W Tam,T Yang-Feng,M Tsubokawa,Clare E. Collins,William J. Henzel,T Le Bon,S Kathuria,Ellson Y. Chen +9 more
TL;DR: The complete primary structure of the human IGF‐I receptor from cloned cDNA is determined and the deduced sequence predicts a 1367 amino acid receptor precursor, including a 30‐residue signal peptide, which is removed during translocation of the nascent polypeptide chain.
Structure of human epidermal growth factor receptor and expression of normal and variant mRNAs in epidermoid carcinoma cells
Axel Ullrich,Lisa M. Coussens,Joel S. Hayflick,Thomas J. Dull,Alane M. Gray,A W Tam,Je Sang Lee,T. Y. Yarden,Towia A. Libermann,Joseph Schlessinger,Julian Downward,Nigel Whittle,Mike Waterfield,Seeburg Peter Horst +13 more