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Towia A. Libermann
Researcher at Beth Israel Deaconess Medical Center
Publications - 284
Citations - 34216
Towia A. Libermann is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Transcription factor & Gene expression. The author has an hindex of 73, co-authored 265 publications receiving 31914 citations. Previous affiliations of Towia A. Libermann include Memorial Sloan Kettering Cancer Center & Brigham and Women's Hospital.
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Journal ArticleDOI
Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia
Sharon Maynard,Jiang Yong Min,Jaime R. Merchan,Kee-Hak Lim,Jianyi Li,Susanta Mondal,Towia A. Libermann,James P. Morgan,Frank W. Sellke,Isaac E. Stillman,Franklin H. Epstein,Vikas P. Sukhatme,S. Ananth Karumanchi +12 more
TL;DR: It is confirmed that placental soluble fms-like tyrosine kinase 1 (sFlt1), an antagonist of VEGF and placental growth factor (PlGF), is upregulated in preeclampsia, leading to increased systemic levels of sFlt 1 that fall after delivery, and observations suggest that excess circulating sFelt1 contributes to the pathogenesis of preeClampsia.
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Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells
Axel Ullrich,Lisa M. Coussens,Joel S. Hayflick,Thomas J. Dull,Alane M. Gray,A W Tam,Jeffrey E. Lee,Yosef Yarden,Towia A. Libermann,Joseph Schlessinger +9 more
TL;DR: The complete 1,210-amino acid sequence of the human epidermal growth factor (EGF) receptor precursor, deduced from cDNA clones derived from placental and A431 carcinoma cells, reveals close similarity between the entire predicted ν-erb-B mRNA oncogene product and the receptor transmembrane and cytoplasmic domains.
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Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene.
Lisa M. Coussens,Teresa L. Yang-Feng,Yu Cheng Liao,Ellson Y. Chen,Alane M. Gray,John P. McGrath,Peter H. Seeburg,Towia A. Libermann,Joseph Schlessinger,Uta Francke,Arthur D. Levinson,Axel Ullrich +11 more
TL;DR: A novel potential cell surface receptor of the tyrosine kinase gene family has been identified and characterized by molecular cloning and its primary sequence is very similar to that of the human epidermal growth factor receptor and the v-erbB oncogene product.
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Soluble endoglin contributes to the pathogenesis of preeclampsia.
Shivalingappa Venkatesha,Mourad Toporsian,Chun Lam,Jun-ichi Hanai,Tadanori Mammoto,Yeon Mee Kim,Yeon Mee Kim,Yuval Bdolah,Kee-Hak Lim,Hai Tao Yuan,Towia A. Libermann,Isaac E. Stillman,Drucilla J. Roberts,Patricia A. D'Amore,Franklin H. Epstein,Frank W. Sellke,Roberto Romero,Roberto Romero,Vikas P. Sukhatme,Michelle Letarte,S. Ananth Karumanchi +20 more
TL;DR: A novel placenta-derived soluble TGF-β coreceptor, endoglin (sEng), which is elevated in the sera of preeclamptic individuals, correlates with disease severity and falls after delivery, suggest that sEng may act in concert with sFlt1 to induce severe preeclampsia.
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Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin
Towia A. Libermann,Harris R. Nusbaum,Nissim Razon,Richard Kris,Irit Lax,Hermona Soreq,Nigel Whittle,Michael D. Waterfield,Axel Ullrich,Joseph Schlessinger +9 more
TL;DR: 4 of 10 primary brain tumours of glial origin which express levels of EGF receptors that are higher than normal also have amplified EGF receptor genes, suggesting that such altered expression and amplification is a particular feature of certain human tumours.