Abby Oehler

TL;DR: The findings argue that MSA is caused by a unique strain of α-synuclein prions, which is different from the putative prions causing PD and from those causing spontaneous neurodegeneration in TgM83+/+ mice.

TL;DR: The results provide compelling evidence that α-synuclein aggregates formed in the brains of MSA patients are transmissible and, as such, are prions.

TL;DR: In this article, the ability of Aβ aggregates to self-propagate following inoculation into bigenic mice was investigated using bioluminescence imaging (BLI).

TL;DR: It is concluded that at least two distinct strains of Aβ prions can be discerned in the brains of Alzheimer’s disease patients and that strain fidelity was preserved on serial passage in mice.

TL;DR: Improved bioassay using selective precipitation of tau prions from human PSP brain homogenates before infection of the HEK cells is reported, providing compelling evidence that PSP and MSA are prion diseases and that MSA is caused by several distinct prion strains.