L
Lea T. Grinberg
Researcher at University of California, San Francisco
Publications - 360
Citations - 20190
Lea T. Grinberg is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Dementia & Medicine. The author has an hindex of 60, co-authored 297 publications receiving 14576 citations. Previous affiliations of Lea T. Grinberg include University of California, Los Angeles & University of California, Berkeley.
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Journal ArticleDOI
Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled‐up primate brain
Frederico A. C. Azevedo,Ludmila R.B. Carvalho,Lea T. Grinberg,José Marcelo Farfel,Renata E.L. Ferretti,Renata Elaine Paraizo Leite,Wilson Jacob Filho,Roberto Lent,Suzana Herculano-Houzel +8 more
TL;DR: The findings challenge the common view that humans stand out from other primates in their brain composition and indicate that, with regard to numbers of neuronal and nonneuronal cells, the human brain is an isometrically scaled‐up primate brain.
Journal ArticleDOI
Primary age-related tauopathy (PART): a common pathology associated with human aging
John F. Crary,John Q. Trojanowski,Julie A. Schneider,Jose F. Abisambra,Erin L. Abner,Irina Alafuzoff,Steven E. Arnold,Johannes Attems,Thomas G. Beach,Eileen H. Bigio,Nigel J. Cairns,Dennis W. Dickson,Marla Gearing,Lea T. Grinberg,Lea T. Grinberg,Patrick R. Hof,Bradley T. Hyman,Kurt A. Jellinger,Gregory A. Jicha,Gabor G. Kovacs,David S. Knopman,Julia Kofler,Walter A. Kukull,Ian R. A. Mackenzie,Eliezer Masliah,Ann C. McKee,Thomas J. Montine,Melissa E. Murray,Janna H. Neltner,Ismael Santa-Maria,William W. Seeley,Alberto Serrano-Pozo,Michael L. Shelanski,Thor D. Stein,Masaki Takao,Dietmar Rudolf Thal,Jonathan B. Toledo,Juan C. Troncoso,Jean Paul G. Vonsattel,Charles L. White,Thomas Wisniewski,Randall L. Woltjer,Masahito Yamada,Peter T. Nelson +43 more
TL;DR: A new term is recommended, “primary age-related tauopathy” (PART), to describe a pathology that is commonly observed in the brains of aged individuals, yet this pathological process cannot be specifically identified pre-mortem at the present time.
Journal ArticleDOI
Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration
Nigel J. Cairns,Eileen H. Bigio,Ian R. A. Mackenzie,Manuela Neumann,Virginia M.-Y. Lee,Kimmo J. Hatanpaa,Charles L. White,Julie A. Schneider,Lea T. Grinberg,Glenda M. Halliday,Charles Duyckaerts,James Lowe,Ida Elisabeth Holm,Markus Tolnay,Koichi Okamoto,Hideaki Yokoo,Shigeo Murayama,John Woulfe,David G. Munoz,Dennis W. Dickson,Paul G. Ince,John Q. Trojanowski,David M. A. Mann +22 more
TL;DR: The aim of this study was to improve the neuropathologic recognition and provide criteria for the pathological diagnosis in the neurodegenerative diseases grouped as frontotemporal lobar degeneration (FTLD) and incorporate up-to-date neuropathology in the light of recent immunohistochemical, biochemical, and genetic advances.
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Distinct tau prion strains propagate in cells and mice and define different tauopathies.
David W. Sanders,Sarah K. Kaufman,Sarah L. DeVos,Apurwa M Sharma,Hilda Mirbaha,Aimin Li,Scarlett J. Barker,Alex C. Foley,Julian R. Thorpe,Louise C. Serpell,Timothy M. Miller,Lea T. Grinberg,William W. Seeley,Marc I. Diamond +13 more
TL;DR: Tau demonstrates essential characteristics of a prion, which might explain the phenotypic diversity of tauopathies and could enable more effective diagnosis and therapy.
Journal ArticleDOI
ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy
Yang Shi,Kaoru Yamada,Shane A. Liddelow,Shane A. Liddelow,Scott T. Smith,Lingzhi Zhao,Wenjie Luo,Richard M. Tsai,Salvatore Spina,Lea T. Grinberg,Julio C. Rojas,Gilbert Gallardo,Kairuo Wang,Joseph Roh,Grace O. Robinson,Mary Beth Finn,Hong Jiang,Patrick Sullivan,Caroline Baufeld,Michael W. Wood,Courtney L. Sutphen,Lena McCue,Chengjie Xiong,Jorge L. Del-Aguila,John C. Morris,Carlos Cruchaga,Alzheimer's Disease Neuroimaging Initiative,Anne M. Fagan,Bruce L. Miller,Adam L. Boxer,William W. Seeley,Oleg Butovsky,Ben A. Barres,Steven M. Paul,David M. Holtzman +34 more
TL;DR: It is demonstrated that ApoE affects tau pathogenesis, neuroinflammation, and tau-mediated neurodegeneration independently of amyloid-β pathology.